NDLI: Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

Content Provider	PubMed Central
Author	Peter, Orendáš Peter, Kubatka Bojková, Bianka Monika, Kassayová Kajo, Karol Výbohová, Desanka Peter, Kružliak Martin, Péč Adamkov, Marián Andrea, Kapinová Adamicová, Katarína Sadloňová, Vladimíra Martina, Chmelová Stollárová, Nadežda
Copyright Year	2014
Abstract	Previous studies in the field of cancer research have suggested a possible role for statins in the reduction of risk in certain malignancies. The purpose of these studies was to examine the chemopreventive effects of pravastatin alone and in combination with pineal hormone melatonin in the N-methyl-N-nitrosourea-induced mammary carcinogenesis model. Pravastatin was given orally (1 00 mg/kg) and melatonin was added to the water (20 μg/ml). Chemoprevention began seven days prior to carcinogen administration and subsequently continued for 15 weeks until autopsy. At autopsy, mammary tumours were removed and prepared for histopathological and immunohistochemical analysis. Parameters of experimental carcinogenesis, mechanism of action (biomarkers of apoptosis, angiogenesis and proliferation) and side effects after long-term treatment in animals were assessed. Pravastatin alone suppressed tumour frequency by 20.5% and average tumour volume by 15% compared with controls. Combined administration of the drugs decreased tumour frequency by 69% and lengthened tumour latency by nine days compared with control animals. The ration between high and low grade carcinomas was apparently reduced in both treated groups. The analysis of carcinoma cells showed significant expression increase in caspase-3 and caspase-7 after pravastatin treatment; however, combined treatment even more pronounced increase in the expression of both caspases. Regarding VEGFR-2 expression, a small effect in carcinomas of both treated groups was found. In plasma metabolism evaluation, pravastatin alone significantly decreased levels of glucose and triacylglycerols. Our results suggest a mild anti-neoplastic effect of pravastatin in this rat mammary gland carcinoma model. Statins co-administered with other suitable drug (e.g. melatonin) should be further evaluated for tumour-preventive properties.
Related Links	http://dx.doi.org/10.1111/iep.12094
Ending Page	410
Page Count	10
Starting Page	401
File Format	PDF
ISSN	09599673
e-ISSN	13652613
Journal	International Journal of Experimental Pathology
Issue Number	6
Volume Number	95
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Pathology and Forensic Medicine Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Susceptibility of the mammary gland to carcinogenesis. III. The cell of origin of rat mammary carcinoma.

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci

The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model

Id4 Regulates Mammary Epithelial Cell Growth and Differentiation and Is Overexpressed in Rat Mammary Gland Carcinomas

Evaluating the response to antioestrogen toremifene treatment in DMBA induced rat mammary carcinoma.

EMT tumorigenesis in the mouse mammary gland

The effect of HeNe laser radiation on the thyroid gland of the rat.

Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours

Tissue distribution of rat macroglobulins in tumour-bearing rats

Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

Similar Documents

Susceptibility of the mammary gland to carcinogenesis. III. The cell of origin of rat mammary carcinoma.

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci

The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model

Id4 Regulates Mammary Epithelial Cell Growth and Differentiation and Is Overexpressed in Rat Mammary Gland Carcinomas

Evaluating the response to antioestrogen toremifene treatment in DMBA induced rat mammary carcinoma.

EMT tumorigenesis in the mouse mammary gland

The effect of HeNe laser radiation on the thyroid gland of the rat.

Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours

Tissue distribution of rat macroglobulins in tumour-bearing rats

Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model