NDLI: Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds

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Annual acknowledgement of manuscript reviewers

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Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds

Content Provider	PubMed Central
Author	Rodriguez, Alberto Martnez, Juan A. Flores, Noem Escalante, Adelfo Gosset, Guillermo Bolivar, Francisco
Abstract	The production of aromatic amino acids using fermentation processes with recombinant microorganisms can be an advantageous approach to reach their global demands. In addition, a large array of compounds with alimentary and pharmaceutical applications can potentially be synthesized from intermediates of this metabolic pathway. However, contrary to other amino acids and primary metabolites, the artificial channelling of building blocks from central metabolism towards the aromatic amino acid pathway is complicated to achieve in an efficient manner. The length and complex regulation of this pathway have progressively called for the employment of more integral approaches, promoting the merge of complementary tools and techniques in order to surpass metabolic and regulatory bottlenecks. As a result, relevant insights on the subject have been obtained during the last years, especially with genetically modified strains of Escherichia coli. By combining metabolic engineering strategies with developments in synthetic biology, systems biology and bioprocess engineering, notable advances were achieved regarding the generation, characterization and optimization of E. coli strains for the overproduction of aromatic amino acids, some of their precursors and related compounds. In this paper we review and compare recent successful reports dealing with the modification of metabolic traits to attain these objectives.
Related Links	http://dx.doi.org/10.1186/s12934-014-0126-z
Starting Page	126
File Format	PDF
ISSN	14752859
e-ISSN	14752859
Journal	Microbial Cell Factories
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Biotechnology Applied Microbiology and Biotechnology Bioengineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Bioengineering Applied Microbiology and Biotechnology Biotechnology

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