NDLI: A Conserved Rule for Pancreatic Islet Organization

Content Provider	PubMed Central
Author	Hoang, Danh-tai Hitomi, Matsunari Nagaya, Masaki Nagashima, Hiroshi Millis, J. Michael Witkowski, Piotr Vipul, Periwal Hara, Manami Jo, Junghyo
Editor	Cai, Tao
Copyright Year	2014
Abstract	Morphogenesis, spontaneous formation of organism structure, is essential for life. In the pancreas, endocrine , , and cells are clustered to form islets of Langerhans, the critical micro-organ for glucose homeostasis. The spatial organization of endocrine cells in islets looks different between species. Based on the three-dimensional positions of individual cells in islets, we computationally inferred the relative attractions between cell types, and found that the attractions between homotypic cells were slightly, but significantly, stronger than the attractions between heterotypic cells commonly in mouse, pig, and human islets. The difference between cell attraction and cell attraction was minimal in human islets, maximizing the plasticity of islet structures. Our result suggests that although the cellular composition and attractions of pancreatic endocrine cells are quantitatively different between species, the physical mechanism of islet morphogenesis may be evolutionarily conserved.
Related Links	http://dx.doi.org/10.1371/journal.pone.0110384
Starting Page	110384
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	10
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-10-28
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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