NDLI: Diagnosing the severity of dry eye: a clear and practical algorithm

Content Provider	PubMed Central
Author	Baudouin, Christophe Aragona, Pasquale Setten, Gysbert Van Rolando, Maurizio Murat, Irkeç Castillo, José Benítez Del Geerling, Gerd Marc, Labetoulle Bonini, Stefano
Copyright Year	2014
Abstract	Dry eye disease (DED) is a distressing ocular condition. Due to its multifactorial nature, clinical and biological signs of DED can be inconsistent and sometimes discordant with symptomatology. Consequently, no gold-standard model for determining DED severity exists. This can impact treatment decisions and complicate evaluation of disease progression, particularly within the stringent context of clinical trials. The multinational ODISSEY European Consensus Group is comprised of ophthalmologists who contend with ocular surface disease issues on a daily basis. This group convened to establish a clear and practical algorithm for evaluation and diagnosis of severe DED. Using a consensus-based approach, they assessed 14 commonly used DED severity criteria. The panel agreed that following confirmed DED diagnosis, just two criteria, symptom-based assessment and corneal fluorescein staining were sufficient to diagnose the presence of severe DED in the majority of patients. In the event of discordance between signs and symptoms, further evaluation using additional determinant criteria was recommended. This report presents the ODISSEY European Consensus Group recommended algorithm for DED evaluation, which facilitates diagnosis of severe disease even in the event of discordance between signs and symptoms. It is intended that this algorithm will be useful in a clinical and developmental setting.
Related Links	http://dx.doi.org/10.1136/bjophthalmol-2013-304619
Ending Page	1176
Page Count	9
Starting Page	1168
File Format	PDF
ISSN	00071161
e-ISSN	14682079
Journal	The British Journal of Ophthalmology
Issue Number	9
Volume Number	98
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2014-09-01
Access Restriction	Open
Rights Holder	BMJ Publishing Group
Subject Keyword	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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