NDLI: T helper Cytokines in Dry Eye Disease

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T helper Cytokines in Dry Eye Disease

Content Provider	PubMed Central
Author	Pflugfelder, Stephen C. Corrales, Rosa M. Paiva, Cintia S. De
Copyright Year	2013
Abstract	Dry eye is an inflammatory disease that results from activation of innate inflammatory pathways in resident ocular surface cells, as well as cytokines produced by recruited T helper (Th) cells. Cytokines produced by the infiltrating Th cells alter the normal cytokine balance on the ocular surface and cause ocular surface epithelial pathology. Changes in levels of Th cytokines on the ocular surface have been measured in dry eye and the biological effects of these cytokines have been documented in experimental culture and mouse model systems. The Th2 cytokine IL-13 has a homeostatic role in promoting goblet cell differentiation. In contrast, The Th1 cytokine IFN-γ antagonizes IL-13 and promotes apoptosis and squamous metaplasia of the ocular surface epithelia. The Th17 cytokine, IL-17 promotes corneal epithelial barrier disruption. The ocular surface epithelium expresses receptors to all of these Th cytokines. Therapies that maintain normal IL-13 signaling, or suppress IFN- γ and IL-17 have potential for treating the ocular surface disease of dry eye.
Related Links	http://dx.doi.org/10.1016/j.exer.2013.08.013
File Format	PDF
ISSN	00144835
e-ISSN	10960007
Journal	Experimental eye research
Volume Number	117
Language	English
Publisher Date	2013-12-01
Access Restriction	Open
Subject Keyword	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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