NDLI: Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier

Content Provider	PubMed Central
Author	Jensen, Jens-michael Schütze, Stefan Michael, Förl Martin, Krönke Proksch, Ehrhardt
Copyright Year	1999
Abstract	Epidermal TNF expression increases in response to cutaneous permeability barrier disruption and wound healing. TNF signaling is mediated by acid and neutral sphingomyelinases (A- and N-SMase), which generate ceramide, an important regulator of proliferation, differentiation, and apoptosis. In the epidermis, ceramide is known to be an integral part of the extracellular stratum corneum (SC) lipid bilayers that constitute the permeability barrier of the skin. We show here that topical application of TNF after experimental injury to the SC of hairless mice (hr–/–) enhances barrier repair. In TNF receptor p55–deficient (TNF-R55–deficient) mice (hr+/+), cutaneous barrier repair was delayed compared with wild-type (hr+/+) or TNF-R75–deficient (hr+/+) animals. After barrier disruption in hairless (hr–/–) and wild-type (hr+/+), but not in TNF-R55–deficient (hr+/+) mice, the enzymatic activities of both A-SMase and N-SMase were significantly enhanced. Stimulation of SMase activities was accompanied by an increase in C24-ceramide levels. Most A-SMase activity in hairless mice (hr–/–) was found in the outer epidermal cell layers and colocalized in the lamellar bodies with A-SMase and sphingomyelin. Reduction of epidermal A-SMase activity by the inhibitor imipramine resulted in delayed permeability barrier repair after SC injury. Together, these results suggest that TNF-R55 signaling pathways contribute to cutaneous permeability barrier repair through SMase-mediated generation of ceramide.
Related Links	http://dx.doi.org/10.1172/jci5307
Ending Page	1770
Page Count	10
Starting Page	1761
File Format	PDF
ISSN	00219738
Journal	Journal of Clinical Investigation
Issue Number	12
Volume Number	104
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	1999-12-15
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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