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| Content Provider | PubMed Central |
|---|---|
| Author | Cheng, Jia Tang, Linlin Hong, Qingxiao Ye, Huadan Xu, Xuting Xu, Leiting Shizhong, Bu Wang, Qinwen Dai, Dongjun Jiang, Danjie Duan, Shiwei |
| Copyright Year | 2014 |
| Abstract | Promoter DNA methylation may reflect the interaction between genetic backgrounds and environmental factors in the development of metabolic disorders, including type 2 diabetes (T2D). Calcium/calmodulin-dependent protein kinase 1D (CAMK1D), cryptochrome 2 (CRY2) and calmodulin 2 (CALM2) genes have been identified to be associated with a risk of T2D. Therefore, the aim of the present study was to investigate the contribution of promoter DNA methylation of these genes to the risk of T2D. Using bisulfite pyrosequencing technology, the DNA methylation levels of the CpG dinucleotides within the CAMK1D, CRY2 and CALM2 gene promoters were measured in 48 patients with T2D and 48 age- and gender-matched healthy controls. The results demonstrated that the promoters of these three genes were hypomethylated in the peripheral blood of all the subjects, and DNA methylation of these three genes did not contribute to the risk of T2D. |
| Related Links | http://dx.doi.org/10.3892/etm.2014.1766 |
| Ending Page | 584 |
| Page Count | 6 |
| Starting Page | 579 |
| File Format | |
| ISSN | 17920981 |
| e-ISSN | 17921015 |
| Journal | Experimental and Therapeutic Medicine |
| Issue Number | 2 |
| Volume Number | 8 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2014-06-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Immunology and Microbiology (miscellaneous) Cancer Research Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research 2400/2401 |
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