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| Content Provider | PubMed Central |
|---|---|
| Author | Zhang, Xin Yalcin, Safak Lee, Dung-fang Yeh, Tsung-yin J. Lee, Seung-min Su, Jie Kumar, Mungamuri Sathish Pauline, Rimmelé Kennedy, Marion Sellers, Rani Landthaler, Markus Tuschl, Thomas Chi, Nai-wen Lemischka, Ihor Keller, Gordon Ghaffari, Saghi |
| Copyright Year | 2011 |
| Abstract | Pluripotency of embryonic stem cells (ESCs) is defined by their ability to differentiate into three germ layers and derivative cell types 1-3 and is established by an interactive network of proteins including OCT4 (also known as POU5F1; ref. 4), NANOG (refs 5,6), SOX2 (ref. 7) and their binding partners. The forkhead box O (FoxO) transcription factors are evolutionarily conserved regulators of longevity and stress response whose function is inhibited by AKT protein kinase. FoxO proteins are required for the maintenance of somatic and cancer stem cells 8-13 ; however, their function in ESCs is unknown. We show that FOXO1 is essential for the maintenance of human ESC pluripotency, and that an orthologue of FOXO1 (Foxo1) exerts a similar function in mouse ESCs. This function is probably mediated through direct control by FOXO1 of OCT4 and SOX2 gene expression through occupation and activation of their respective promoters. Finally, AKT is not the predominant regulator of FOXO1 in human ESCs. Together these results indicate that FOXO1 is a component of the circuitry of human ESC pluripotency. These findings have critical implications for stem cell biology, development, longevity and reprogramming, with potentially important ramifications for therapy. |
| Related Links | http://dx.doi.org/10.1038/ncb2293 |
| Ending Page | 1099 |
| Page Count | 8 |
| Starting Page | 1092 |
| File Format | |
| ISSN | 14657392 |
| e-ISSN | 14764679 |
| Journal | Nature cell biology |
| Issue Number | 9 |
| Volume Number | 13 |
| Language | English |
| Publisher Date | 2011-07-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology |
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