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| Content Provider | PubMed Central |
|---|---|
| Author | Ma, Ying-yu Yu, Sheng He, Xu-jun Xu, Yuan Wu, Fang Xia, Ying-jie Guo, Kun Wang, Hui-ju Ye, Zai-yuan Zhang, Wei Tao, Hou-quan |
| Copyright Year | 2014 |
| Abstract | The aim of this study was to discuss the role of c-KIT mutation in the pathogenesis of gastrointestinal stromal tumors (GISTs) and analyze its correlation with proliferation and apoptosis. c-KIT and PDGFRA genotypes were examined by deoxyribonucleic acid sequencing. Immunohistochemistry was performed to determine the expression levels of Kit, Ki-67 (proliferation marker), and apoptotic protease-activating factor (APAF)-1 (apoptosis marker) and the relationship between their three genes. In the 68 cases examined, 44 cases (64.7%) showed mutations in one of the four exons of c-KIT. The mutations were most frequently found in exon 11 (30 cases [44.1%]), followed by exon 9 (ten cases [14.7%]) and exon 13 (four cases [5.9%]). c-KIT mutation showed no association with prognostic factors using the classification of risk of aggressive behavior in GIST proposed by Fletcher et al. No cases had mutated exon 17 of c-KIT, and neither did exon 12, 14, or 18 of PDGFRA in our present study. There was a positive correlation between the expression level of Kit and Ki-67 (R=0.282, P=0.020). Conversely, a negative correlation was found between the expression levels of Kit and APAF1 (R=−0.243, P=0.046). In conclusion, most GISTs with Kit expression showed c-KIT mutation. Kit expression has a positive correlation with Ki-67 and a negative correlation with APAF1, showing that c-KIT is involved in GIST occurrence and development through proliferation promotion and apoptosis inhibition. |
| Related Links | http://dx.doi.org/10.2147/ott.s60458 |
| Ending Page | 643 |
| Starting Page | 637 |
| File Format | |
| ISSN | 11786930 |
| e-ISSN | 11786930 |
| Journal | OncoTargets and therapy |
| Volume Number | 7 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2014-05-01 |
| Access Restriction | Open |
| Rights Holder | Dove Medical Press |
| Subject Keyword | Pharmacology (medical) Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
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