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Recent advances in the treatment of gastrointestinal stromal tumors
| Content Provider | SAGE Publishing |
|---|---|
| Author | Serrano, César George, Suzanne |
| Copyright Year | 2014 |
| Abstract | Constitutively activating mutations in the KIT and platelet-derived growth factor receptor α (PDGFRA) RTKs play a crucial role in the biology of gastrointestinal stromal tumors (GISTs), and this disease has served as an effective model for targeting gain-of-function kinase mutations in cancer. Imatinib has entered the clinical arena in the last decade and substantially improved the outcome in these formerly untreatable cancers. However, most advanced GISTs responding to imatinib progress within 2–3 years due to heterogeneous subclones harboring a range of imatinib-resistant secondary KIT mutations. Sunitinib, and more recently, regorafenib, have obtained US Food and Drug Administration approval for the treatment of GISTs after imatinib failure, and thus expanded the treatment options in resistant disease. Within this framework, we present an evaluation of current GIST management, emphasizing the most recent advances in the field together with a discussion on future steps to be taken in refractory disease. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1758834014522491?download=true |
| Starting Page | 115 |
| Ending Page | 127 |
| Page Count | 13 |
| ISSN | 17588359 |
| Issue Number | 3 |
| Volume Number | 6 |
| Journal | Therapeutic Advances in Medical Oncology (TAM) |
| e-ISSN | 17588359 |
| DOI | 10.1177/1758834014522491 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2014-02-18 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2014 |
| Subject Keyword | gastrointestinal stromal tumors c-KIT nilotinib regorafenib sunitinib masitinib sorafenib imatinib |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
