NDLI: Fluorescence Excitation Spectrum of Bilirubin in Blood: A Model for the Action Spectrum for Phototherapy of Neonatal Jaundice†

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Fluorescence Excitation Spectrum of Bilirubin in Blood: A Model for the Action Spectrum for Phototherapy of Neonatal Jaundice†

Content Provider	PubMed Central
Author	Lamola, Angelo A. Russo, Marie
Abstract	A recent report (Lamola et al. 2013 Pediatric Research, 74, 54–60) presents a semi-empirical model for facile calculation of an action spectrum for bilirubin photochemistry in vivo using the most current knowledge of the optics of neonatal skin. The calculations indicate that competition for phototherapy light by hemoglobin in the skin is the predominant factor that defines the spectrum of light absorbed by bilirubin. If the latter is correct, a valid physical analog of the calculated spectrum is the excitation spectrum of bilirubin in blood. The fluorescence excitation spectrum was recorded and, indeed, found to be very similar to the calculated spectrum. Both spectra exhibit maxima near 476 nm and widths at half height of about 50 nm. This result supports the conclusion that light between 460 and 490 nm is most effective for phototherapy of neonatal jaundice.
Related Links	http://dx.doi.org/10.1111/php.12167
Ending Page	296
Page Count	3
Starting Page	294
File Format	PDF
ISSN	00318655
e-ISSN	17511097
Journal	Photochemistry and photobiology
Issue Number	2
Volume Number	90
Language	English
Publisher Date	2014-03-01
Access Restriction	Open
Subject Keyword	Physical and Theoretical Chemistry Biochemistry Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Physical and Theoretical Chemistry Radiation

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