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| Content Provider | PubMed Central |
|---|---|
| Author | Xuan, Ye Zeng, Huiqing Ning, Gang Reiter, Jeremy F. Liu, Aimin |
| Abstract | The primary cilium is a hair-like cell surface organelle, the loss of which leads to numerous human diseases collectively known as ciliopathies. To better understand the pathology and to develop treatments for these diseases, it is critical to identify important regulators of cilium biogenesis and to reveal their mechanisms of function. We show that C2cd3 is required for the assembly of a structure at the distal end of the mother centriole, which serves as an anchor of the cilium. Without this structure, the mother centriole cannot associate with the membrane, and many other cilium proteins cannot be recruited to the centriole. This work provides a significant insight into one of the earliest steps in cilium formation. |
| Related Links | http://dx.doi.org/10.1073/pnas.1318737111 |
| Ending Page | 2169 |
| Page Count | 6 |
| Starting Page | 2164 |
| File Format | |
| ISSN | 10916490 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-02-11 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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