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| Content Provider | PubMed Central |
|---|---|
| Author | Pavel, Plevka Lim, Pei-yin Perera, Rushika Cardosa, Jane Suksatu, Ampa Kuhn, Richard J. Rossmann, Michael G. |
| Abstract | Enterovirus 71 (EV71) causes yearly outbreaks of hand, foot, and mouth disease in Southeast Asian countries including China and Malaysia. Some of the infected children develop encephalitis that can be fatal or result in permanent brain damage. There are no anti-EV71 therapeutic agents available. Here it is shown that an antibody that had been generated by using an immature EV71 virus as an antigen induced the release of genome from EV71 virions, rendering the virus noninfectious. The induction of genome release is a mechanism by which antibodies can neutralize viruses. Furthermore, the approach presented in the paper could be used to prepare antibodies with similar properties against related viruses that include significant human pathogens. |
| Related Links | http://dx.doi.org/10.1073/pnas.1320624111 |
| Ending Page | 2139 |
| Page Count | 6 |
| Starting Page | 2134 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-02-11 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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