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| Content Provider | PubMed Central |
|---|---|
| Author | Kwon, So Young Park, Sang Hoon Yeon, Jong Eun Jeong, Sook Hyang Kwon, Oh Sang Lee, Jin Woo Kim, Hong Soo Seo, Yeon Seok Kim, Young Seok Sohn, Joo Hyun Yim, Hyung Joon Choi, Jong Young Lee, Myung Seok Kweon, Young Oh Cheong, Jae Youn Kim, Haak Cheoul Lee, Heon Ju Baik, Soon Koo An, Hyonggin Byun, Kwan Soo |
| Copyright Year | 2014 |
| Abstract | The aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea. |
| Related Links | http://dx.doi.org/10.3346/jkms.2014.29.2.248 |
| Ending Page | 253 |
| Page Count | 6 |
| Starting Page | 248 |
| File Format | |
| ISSN | 10118934 |
| e-ISSN | 15986357 |
| Journal | Journal of Korean Medical Science |
| Issue Number | 2 |
| Volume Number | 29 |
| Language | English |
| Publisher | The Korean Academy of Medical Sciences |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Rights Holder | The Korean Academy of Medical Sciences |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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