NDLI: Non-Uniform Membrane Diffusion Enables Steady-State Cell Polarization via Vesicular Trafficking

Please wait, while we are loading the content...

Year: 2016, Volume: 7

Year: 2015, Volume: 6

Year: 2015, Volume: 2

Year: 2015, Volume: 0

Year: 2014, Volume: 5

Year: 2014, Volume: 4

Year: 2013, Volume: 4

Year: 2013, Volume: 4, Issue: Unspecified

Rapid internal contraction boosts DNA friction

Magnetic switching of ferroelectric domains at room temperature in multiferroic PZTFT

A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration

Single-mode tunable laser emission in the single-exciton regime from colloidal nanocrystals

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery

Osmium isotope evidence for a large Late Triassic impact event

Auto-production of biosurfactants reverses the coffee ring effect in a bacterial system

Widespread sex differences in gene expression and splicing in the adult human brain

Self-similarity of contact line depinning from textured surfaces

Crosstalk between KLF4 and STAT3 regulates axon regeneration

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

Quantum mechanical which-way experiment with an internal degree of freedom

Tuneable enhancement of the salt and thermal stability of polymeric micelles by cyclized amphiphiles

Corrigendum: Genome sequences of wild and domestic bactrian camels

Carbon nanotubes on a spider silk scaffold

Initialized near-term regional climate change prediction

Rapid changes in the electrical state of the 1999 Izmit earthquake rupture zone

PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition

Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21

Observation and theory of X-ray mirages

CAND1 controls in vivo dynamics of the Cullin 1-RING ubiquitin ligase repertoire

Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

Forced Protein Unfolding Leads to Highly Elastic and Tough Protein Hydrogels

Gate control of the electron spin-diffusion length in semiconductor quantum wells

Quantum engineering at the silicon surface using dangling bonds

Acoustic dynamics of network-forming glasses at mesoscopic wavelengths

Hydrogenosomes in the diplomonad Spironucleus salmonicida

Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus

In situ atomic-scale observation of continuous and reversible lattice deformation beyond the elastic limit

Structural and functional characterization of two alpha-synuclein strains

Critical fictive temperature for plasticity in metallic glasses

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

Single-photon-level quantum image memory based on cold atomic ensembles

Regulation of the DNA damage response on male meiotic sex chromosomes

Magnetically ultraresponsive nanoscavengers for next-generation water purification systems

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

LANDSCAPE OF THE MITOCHONDRIAL Hsp90 METABOLOME IN TUMORS

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

Signatures of the electronic nature of pairing in high-T c superconductors obtained by non-equilibrium boson spectroscopy

Wall teichoic acid structure governs horizontal gene transfer between major bacterial pathogens

Sulfhydration mediates neuroprotective actions of parkin

Primary sensory cortices contain distinguishable spatial patterns of activity for each sense

InVERT molding for scalable control of tissue microarchitecture

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

Structure of a helicase–helicase loader complex reveals insights into the mechanism of bacterial primosome assembly

Realistic Control of Network Dynamics

Controlled formation and reflection of a bright solitary matter-wave

Functional anatomy of an allosteric protein

High genome heterozygosity and endemic genetic recombination in the wheat stripe rust fungus

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

Genome-wide search for exonic variants affecting translational efficiency

Dynamics and stoichiometry of a regulated enhancer-binding protein in live Escherichia coli cells

Evolution of the average avalanche shape with the universality class

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis

Genome sequence of the date palm Phoenix dactylifera L

Topological structure dynamics revealing collective evolution in active nematics

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Scaling laws for van der Waals interactions in nanostructured materials

Near-ideal theoretical strength in gold nanowires containing angstrom scale twins

Pirt Functions as an Endogenous Regulator of TRPM8

Heterovalent cation substitutional doping for quantum dot homojunction solar cells

High-resolution three-dimensional mapping of mRNA export through the nuclear pore

Amorphous nickel hydroxide nanospheres with ultrahigh capacitance and energy density as electrochemical pseudocapacitor materials

Identity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Level

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

Genetic control of inflorescence architecture during rice domestication

A cholinergic trigger drives learning-induced plasticity at hippocampal synapses

Sublinear Binocular Integration Preserves Orientation Selectivity in Mouse Visual Cortex

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Automatic protein structure solution from weak X-ray data

High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics

Constitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice

Direct imaging of single UvrD helicase dynamics on long single-stranded DNA

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Spiral resonators for on-chip laser frequency stabilization

Perceiving Invisible Light through a Somatosensory Cortical Prosthesis

Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development

Observation of possible topological in-gap surface states in the Kondo insulator SmB6 by photoemission

A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction

Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Relation between the nodal and antinodal gap and critical temperature in superconducting Bi2212

Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

Differential temperature operation of plant immune responses

Sodium and potassium competition in potassium-selective and non-selective channels

Distinguishing between yield advances and yield plateaus in historical crop production trends

Variability in visual cortex size reflects tradeoff between local orientation sensitivity and global orientation modulation

Conducting linear chains of sulphur inside carbon nanotubes

Corrigendum: High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

Draft genome sequence of the Tibetan antelope

Ultrafast charge localization in a stripe-phase nickelate

Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

Nematic twist-bend phase with nanoscale modulation of molecular orientation

Tomonaga–Luttinger physics in electronic quantum circuits

Autophagy proteins regulate ERK phosphorylation

Caribbean-wide decline in carbonate production threatens coral reef growth

In vivo recordings of brain activity using organic transistors

Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen

Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65

Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules

Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae

Leg-tracking and automated behavioural classification in Drosophila

A hyperpolarized equilibrium for magnetic resonance

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases

Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination

Erratum: Fcp1-dependent dephosphorylation is required for M-phase-promoting factorinactivation at mitosis exit

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells

Top–down fabrication of sub-nanometre semiconducting nanoribbons derived from molybdenum disulfide sheets

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication

Postsynaptic current bursts instruct action potential firing at a graded synapse

Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage

Bio-responsive polymer hydrogels homeostatically regulate blood coagulation

FAK-heterozygous mice display enhanced tumour angiogenesis

COORDINATED ACTIVATION OF THE RAC-GAP β2-CHIMAERIN BY AN ATYPICAL PROLINE-RICH DOMAIN AND DIACYLGLYCEROL

Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

Non-Uniform Membrane Diffusion Enables Steady-State Cell Polarization via Vesicular Trafficking

AtALMT9 is a malate-activated vacuolar chloride channel required for stomatal opening in Arabidopsis

Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss

Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans

Graphene-based in-plane micro-supercapacitors with high power and energy densities

Long-distance distribution of genuine energy-time entanglement

Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression

R-Spondin 2 signaling mediates susceptibility to fatal infectious diarrhea

Magnetic Barcode Assay for Genetic Detection of Pathogens

Chiral plasmonic DNA nanostructures with switchable circular dichroism

Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels

Multipolar radiation of quantum emitters with nanowire optical antennas

Control of the conformations of ion Coulomb crystals in a Penning trap

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans

Time-calibrated Milankovitch cycles for the late Permian

Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton

Extraordinary phylogenetic diversity and metabolic versatility in aquifer sediment

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

DNA directed self-assembly of shape-controlled hydrogels

A comprehensive multiscale framework for simulating optogenetics in the heart

A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue

Restricted perinatal retinal degeneration induces retina reshaping and correlated structural rearrangement of the retinotopic map

Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility

Erratum: GaAs nanopillar-array solar cells employing in situ surface passivation

Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation

Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

COG complexes form spatial landmarks for distinct SNARE complexes

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

Oxygen-driven anisotropic transport in ultra-thin manganite films

A nanometre-scale resolution interference-based probe of interfacial phenomena between microscopic objects and surfaces

Ligand binding and aggregation of pathogenic SOD1

Corrigendum: A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

Rapid regional perturbations to the recent global geomagnetic decay revealed by a new Hawaiian record

Cyclin D1 Induction of Dicer Governs MicroRNA Processing and Expression in Breast Cancer

The tiger genome and comparative analysis with lion and snow leopard genomes

Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library

An integrated approach to realizing high-performance liquid-junction quantum dot sensitized solar cells

A new class of plant lipid is essential for protection against phosphorus depletion

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

Carbon dioxide concentration dictates alternative methanogenic pathways in oil reservoirs

IGF-1 promotes the development and cytotoxic activity of human NK cells

A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates

Probing relaxation times in graphene quantum dots

The endoskeletal origin of the turtle carapace

Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo

Calfacilitin is a calcium channel modulator essential for initiation of neural plate development

Atomistics of vapour–liquid–solid nanowire growth

Selection on hemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses

Large fiber size in skeletal muscle is metabolically advantageous

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Corrigendum: Critical fictive temperature for plasticity in metallic glasses

Strongly enhanced flux pinning in one-step deposition of BaFe2(As0.66P0.33)2 superconductor films with uniformly dispersed BaZrO3 nanoparticles

Increased ventilation of Antarctic deep water during the warm mid-Pliocene

A new protein complex promoting the assembly of Rad51 filaments

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Ultrafast modulation of polarization amplitude by terahertz fields in electronic-type organic ferroelectrics

DNA repair choice defines a common pathway for recruitment of chromatin regulators

Interactions between Twist and other core epithelial–mesenchymal transition factors are controlled by GSK3-mediated phosphorylation

Impaired endolysosomal function disrupts Notch signaling in optic nerve astrocytes

Mechanism of microtubule array expansion in the cytokinetic phragmoplast

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

A pairwise maximum entropy model accurately describes resting-state human brain networks

A model of parity-dependent immunity to placental malaria

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Unraveling quantum pathways using optical 3D Fourier-transform spectroscopy

Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis

Impact of macromolecular crowding on DNA replication

A peptide probe for targeted brown adipose tissue imaging

Polariton condensation in solitonic gap states in a one-dimensional periodic potential

Doping dependence of spin excitations and its correlations with high-temperature superconductivity in iron pnictides

Reconstructing targetable pathways in lung cancer by integrating diverse omics data

Disorder strongly enhances Auger recombination in conductive quantum-dot solids

A solid with a hierarchical tetramodal micro-meso-macro pore size distribution

Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci

Compact designer TALENs for efficient genome engineering

Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture

Molecular mechanics of mineralized collagen fibrils in bone

Analysis of protein coding mutations in hiPSCs and their possible role during somatic cell reprogramming

Helicity-dependent single-walled carbon nanotube alignment on graphite for helical angle and handedness recognition

A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors

Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila

Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer

UTX coordinates steroid hormone-mediated autophagy and cell death

Increasing functional modularity with residence time in the co-distribution of native and introduced vascular plants

Activity-Dependent Regulation of Dendritic Growth and Maintenance by Glycogen Synthase Kinase 3β

Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups

Asymmetric selection and the evolution of extraordinary defences

Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Observations from old forests underestimate climate change effects on tree mortality

Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control

Regulation of A20 and other OTU deubiquitinases by reversible oxidation

Reconstructing genome evolution in historic samples of the Irish potato famine pathogen

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Quasi-monoenergetic laser-plasma acceleration of electrons to 2 GeV

Xenoturbella bocki exhibits direct development with similarities to Acoelomorpha

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

Hemogenic endocardium contributes to transient definitive hematopoiesis

Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering

Dual role of myosin II during Drosophila imaginal disc metamorphosis

Gate sequence for continuous variable one-way quantum computation

The p53–PUMA axis suppresses iPSC generation

Capture and conversion of CO2 at ambient conditions by a conjugated microporous polymer

Zscan4 restores the developmental potency of embryonic stem cells

Calix[n]imidazolium as a new class of positively charged homo-calix compounds

Corrigendum: Polariton condensation in solitonic gap states in a one-dimensional periodic potential

Topological quantum computing with a very noisy network and local error rates approaching one percent

Transgenerational gene silencing causes gain of virulence in a plant pathogen

Far-red light photoactivatable near-infrared fluorescent proteins engineered from a bacterial phytochrome

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signaling

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

Control of the spin geometric phase in semiconductor quantum rings

Temperature and magnetic field dependence of a Kondo system in the weak coupling regime

In Vivo Time-gated Fluorescence Imaging with Biodegradable Luminescent Porous Silicon Nanoparticles

Disrupting malaria parasite AMA1 – RON2 interaction with a small molecule prevents erythrocyte invasion

DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2

Corrigendum: Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropsis gaditana

Greater efficiency of photosynthetic carbon fixation due to single amino-acid substitution

Nanoscale light–matter interactions in atomic cladding waveguides

Transmission-blocking interventions eliminate malaria from laboratory populations

One mechanism contributing to co-variability of the Atlantic inflow branches to the Arctic

Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

Numerical processing in the human parietal cortex during experimental and natural conditions

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

B7-H5 costimulates human T cells via CD28H

Coherent diffraction imaging of nanoscale strain evolution in a single crystal under high pressure

RNA editing regulates transposon-mediated heterochromatic gene silencing

Aerosol transmission is an important mode of influenza A virus spread

Active cochlear amplification is dependent on supporting cell gapjunctions

Bactericidal activity of black silicon

Ribosome profiling reveals features of normal and disease-associated mitochondrial translation

Attosecond nonlinear optics using gigawatt-scale isolated attosecond pulses

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalisation

Improving palm oil quality through identification and mapping of the lipase gene causing oil deterioration

Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery

Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy

Two FLX family members are non-redundantly required to establish the vernalization requirement in Arabidopsis

Parasympathetic stimulation improves epithelial organ regeneration

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

NMR spectroscopic detection of chirality and enantiopurity in referenced systems without formation of diastereomers

Optical sinc-shaped Nyquist pulses of exceptional quality

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy

Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension During Renal Tubular Morphogenesis

Acid sensing by sweet and bitter taste neurons in Drosophila melanogaster

Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1

High charge-carrier mobility enables exploitation of carrier multiplication in quantum-dot films

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

The impact of sleep deprivation on food desire in the human brain

Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform

Measurement of the first ionization potential of astatine by laser ionization spectroscopy

Semiclassical Monte-Carlo approach for modelling non-adiabatic dynamics in extended molecules

The evolution and pathogenic mechanisms of the rice sheath blight pathogen

Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography

Hydrogen-induced nanotunnel opening within semiconductor subsurface

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons

Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

Green chemistry and nanofabrication in a levitated Leidenfrost drop

Efficient and tunable white-light emission of metal–organic frameworks by iridium-complex encapsulation

Attomolar DNA detection with chiral nanorod assemblies

The pore of voltage-gated potassium ion channels is strained when closed

Measurement of crystal growth velocity in a melt-quenched phase-change material

Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signaling pathways

Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type

Linkage control between molecular and supramolecular chirality in 21-helical hydrogen-bonded networks using achiral components

Anisotropic two-dimensional electron gas at the LaAlO3/SrTiO3 (110) interface

A search for varying fundamental constants using hertz-level frequency measurements of cold CH molecules

Super liquid-repellent gas membranes for carbon dioxide capture and heart–lung machines

Plasmon-mediated magneto-optical transparency

A rational design of cosolvent exfoliation of layered materials by directly probing liquid–solid interaction

Vibrational near-field mapping of planar and buried three-dimensional plasmonic nanostructures

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Confinement of pyridinium hemicyanine dye within an anionic metal-organic framework for two-photon-pumped lasing

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

One hundred fold increase in current carrying capacity in a carbon nanotube–copper composite

An ex vivo Gene Therapy Approach to Treat Muscular Dystrophy Using inducible Pluripotent Stem Cells

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

Description and first application of a new technique to measure the gravitational mass of antihydrogen

Role of domain walls in the abnormal photovoltaic effect in BiFeO3

FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Designing tensile ductility in metallic glasses

Repeated targeting of the same hosts by a brood parasite compromises host egg rejection

Telomeres shorten at equivalent rates in somatic tissues of adults

Experimental recovery of quantum correlations in absence of system-environment back-action

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice

Correlation between spin structure oscillations and domain wall velocities

Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism

Genome-scale Proteome Quantification by DEEP SEQ Mass Spectrometry

TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death

Structure of dual receptor binding to botulinum neurotoxinB

Mid-Pliocene warm-period deposits in the High Arctic yield insight into camel evolution

Use of domesticated pigs by Mesolithic hunter-gatherers in northwestern Europe

Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

High transconductance organic electrochemical transistors

Src activation by β-adrenoreceptors is a key switch for tumor metastasis

Fork sensing and strand switching control antagonistic activities of RecQ helicases

Homeostatic regulation of dendritic dynamics in a motor map in vivo

Rare-earth-doped biological composites as in vivo shortwave infrared reporters

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

BRCA1 and CtIP suppress long tract gene conversion between sister chromatids

Baiji genomes reveal low genetic variability and new insights into secondary aquatic adaptations

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells

Exact controllability of complex networks

Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction

Parallel photonic information processing at gigabyte per second data rates using transient states

Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila

Genome signature-based dissection of human gut metagenomes to extract subliminal viral sequences

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

Doped organic transistors operating in the inversion and depletion regime

Sox17 is indispensable for acquisition and maintenance of arterial identity

Atomically precise edge chlorination of nanographenes and its application in graphene nanoribbons

A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells

Globally homochiral assembly of two-dimensional molecular networks triggered by co-absorbers

Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction

Tribbles 3 Mediates Endoplasmic Reticulum Stress-Induced Insulin Resistance in Skeletal Muscle

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signaling pathway

DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control

PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression

Metamaterial fibres for subdiffraction imaging and focusing at terahertz frequencies over optically long distances

TRPM2 links oxidative stress to the NLRP3 inflammasome activation

Collagen VI regulates satellite cell self-renewal and muscle regeneration

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics

Species differences and molecular determinant of TRPA1 cold sensitivity

Structural insights into protein-only RNase P complexed with tRNA

Measuring long-range carrier diffusion across multiple grains in polycrystalline semiconductors by photoluminescence imaging

Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology

Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons

Stable platinum nanoclusters on genomic DNA–graphene oxide with a high oxygen reduction reaction activity

Three-dimensional optical holography using a plasmonic metasurface

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues

Desktop Nanofabrication with Massively Multiplexed Beam Pen Lithography

Resource heterogeneity can facilitate cooperation

In-situ ultra-sensitive infrared absorption spectroscopy of biomolecule interactions in real time with plasmonic nanoantennas

A nanopore machine promotes the vectorial transport of DNA across membranes

Strong Casimir force reduction through metallic surface nanostructuring

FTO-Mediated Formation of N 6-Hydroxymethyladenosine and N 6-Formyladenosine in Mammalian RNA

Suppression of population transport and control of exciton distributions by entangled photons

Natural gold particles in Eucalyptus leaves and their relevance to exploration for buried gold deposits

Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

PhyloPhlAn is a new method for improved phylogenetic and taxonomic placement of microbes

A synthetic route to ultralight hierarchically micro/mesoporous Al(III)-carboxylate metal-organic aerogels

Mid-infrared optical frequency combs at 2.5 μm based on crystalline microresonators

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells

Free-electron gas at charged domain walls in insulating BaTiO3

Microcavity controlled coupling of excitonic qubits

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

Non-invasive in vivo assessment of IDH1 mutational status in glioma

PI3P regulates sorting and processing of amyloid precursor protein through the endosomal system

RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

A platform for designing hyperpolarized magnetic resonance chemical probes

The unusual dynamics of parasite actin result from isodesmic polymerization

Human endonuclease V is a ribonuclease specific for inosine-containing RNA

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

Sequestration of Martian CO2 by mineral carbonation

Evolutionary instability of zero-determinant strategies demonstrates that winning is not everything

Active and stable carbon nanotube/nanoparticle composite electrocatalyst for oxygen reduction

GaAs nanopillar-array solar cells employing in situ surface passivation

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

Trunk exoskeleton in teleosts is mesodermal in origin

Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency

Nano-structured smart hydrogels with rapid response and high elasticity

Tumor-Associated Mutant p53 Drives the Warburg Effect

Genome of the red alga Porphyridium purpureum

Effective localized collection and identification of airborne species through electrodynamic precipitation and SERS-based detection

Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions

Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus

Draft genome of the kiwifruit Actinidia chinensis

Srs2 prevents Rad51 filament formation by repetitive scrunching of DNA

Tumour angiogenesis regulation by the miR-200 family

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA

Flash freezing route to mesoporous polymer nanofibre networks

Two-colour pump–probe experiments with a twin-pulse-seed extreme ultraviolet free-electron laser

Erratum: Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice

Reactivity mapping with electrochemical gradients for monitoring reactivity at surfaces in space and time

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

Three-dimensional strutted graphene grown by substrate-free sugar blowing for high-power-density supercapacitors

A Reconfigurable Plasmofluidic Lens

Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Rnd3 coordinates early steps of cortical neurogenesis through actin dependent and independent mechanisms

Quality versus quantity of social ties in experimental cooperative networks

Design principle for increasing charge mobility of π-conjugated polymers using regularly localized molecular orbitals

Electrically driven nanobeam laser

Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution

A network of genes connects polyglutamine toxicity to ploidy control in yeast

hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

An on-chip coupled resonator optical waveguide single-photon buffer

Structural basis of AMPK regulation by small molecule activators

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells

Determining the optimum morphology in high-performance polymer-fullerene organic photovoltaic cells

Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics

A European population in Minoan Bronze Age Crete

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Vibrationally induced inversion of photoelectron forward-backward asymmetry in chiral molecule photoionization by circularly polarized light

Nonvolatile liquid anthracenes for facile full-colour luminescence tuning at single blue-light excitation

A C-terminal PDZ domain binding sequence is required for striatal distribution of the dopamine transporter

SUMO2/3 modification of cyclin E contributes to the control of replication origin firing

Human-relevant Levels of Added Sugar Consumption Increase Female Mortality and Lower Male Fitness in Mice

Protein analysis by time-resolved measurements with an electro-switchable DNA chip

High-throughput hyperdimensional vertebrate phenotyping

Biologically enhanced cathode design for improved capacity and cycle life for lithium-oxygen batteries

Ultrafast universal quantum control of a quantum-dot charge qubit using Landau–Zener–Stückelberg interference

Cyclic electron flow is redox-controlled but independent of state transition

Role of point defects on the reactivity of reconstructed anatase titanium dioxide (001) surface

Master regulators of FGFR2 signalling and breast cancer risk

Val66Met Polymorphism of BDNF Alters Prodomain Structure to Induce Neuronal Growth Cone Retraction

Real-Time Influenza Forecasts during the 2012–2013 Season

Visualization and quantification of transition metal atomic mixing in Mo1−x W x S2 single layers

Visualizing influenza virus infection in living mice

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment

Dynamic Self-Stiffening in Liquid Crystal Elastomers

The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing

In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

Integrating DNA strand-displacement circuitry with DNA tile self-assembly

Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

Cdkn1b overexpression in adult mice alters the balance between genome and tissue aging

A Munc13-like protein in Arabidopsis mediates H+-ATPase translocation that is essential for stomatal responses

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11

α–SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro

Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

The TSC-mTOR pathway regulates macrophage polarization

Omnidirectional spin-wave nanograting coupler

Engineering three-dimensional topological insulators in Rashba-type spin-orbit coupled heterostructures

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Non-volatile memory based on the ferroelectric photovoltaic effect

Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Nanobatteries in redox-based resistive switches require extension of memristor theory

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

Active structuring of colloidal armour on liquid drops

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion

Distinct iron isotopic signatures and supply from marine sediment dissolution

A versatile cis-acting inverter module for synthetic translational switches

Strong coupling in the sub-wavelength limit using metamaterial nanocavities

The basis for limited specificity and MHC restriction in a T cell receptor interface

A chiral-based magnetic memory device without a permanent magnet

LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition

Recruitment of Mesenchymal Stem Cells Into Prostate Tumors Promotes Metastasis

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer

Excitation-dependent visible fluorescence in decameric nanoparticles with monoacylglycerol cluster chromophores

FUNCTIONAL EVALUATION OF AUTISM-ASSOCIATED MUTATIONS IN NHE9

A magnetic non-reciprocal isolator for broadband terahertz operation

An experimental test on the probability of extinction of new genetic variants

Regulation of adipose oestrogen output by mechanical stress

Brown fat in a protoendothermic mammal fuels eutherian evolution

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Mutants of Cre recombinase with improved accuracy

Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers

Demonstration of the spin solar cell and spin photodiode effect

Multiplexed biomimetic lipid membranes on graphene by dip-pen nanolithography

Distinct charge dynamics in battery electrodes revealed by in situ and operando soft X-ray spectroscopy

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion

Identification and design principles of low hole effective mass p-type transparent conducting oxides

Unusually stable ~100-fold reversible and instantaneous swelling of inorganic layered materials

CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

Powering the programmed nanostructure and function of gold nanoparticles with catenated DNA machines

All-optical control and visualization of ultrafast two-dimensional atomic motions in a single crystal of bismuth

Conjugated organic framework with three-dimensionally ordered stable structure and delocalized π clouds

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

A role for Piezo2 in EPAC1-dependent mechanical allodynia

Hysteresis of ligand binding in CNGA2 ion channels

Structural basis of protein phosphatase 2A stable latency

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation

Environmental Impact on Direct Neuronal Reprogramming In Vivo in the Adult Brain

The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat

Activation and splitting of carbon dioxide on the surface of an inorganic electride material

Distinct Pathways Mediate Axon Degeneration during Apoptosis and Axon-Specific Pruning

Corrigendum: Ultrafast universal quantum control of a quantum-dot charge qubit using Landau–Zener–Stückelberg interference

A two-atom electron pump

Phantom pain is associated with preserved structure and function in the former hand area

Miz1 is required to maintain autophagic flux

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

Perceptual judgements and chronic imaging of altered odour maps indicate comprehensive stimulus template matching in olfaction

Millisecond charge-parity fluctuations and induced decoherence in a superconducting transmon qubit

Visualization and targeted disruption of protein interactions in living cells

Evidence for distinct human auditory cortex regions for sound location versus identity processing

Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites

G-Quadruplex structures are stable and detectable in human genomic DNA

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Femtolitre chemistry assisted by microfluidic pen lithography

A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice

Activation and Characterization of a Cryptic Polycyclic Tetramate Macrolactam Biosynthetic Gene Cluster

Noble metal nanoclusters and nanoparticles precede mineral formation in magmatic sulphide melts

A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel

PI3K-GSK3 signaling regulates mammalian axon regeneration by inducing the expression of Smad1

Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Human hypocretin and melanin concentrating hormone levels are linked to emotion and social interaction

A polymer tandem solar cell with 10.6% power conversion efficiency

Genetic design of enhanced valley splitting towards a spin qubit in silicon

Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

A truncated Wnt7a retains full biological activity in skeletal muscle

MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1

Inferring tumour purity and stromal and immune cell admixture from expression data

Ocean lead at the termination of the Younger Dryas cold spell

Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses

A common functional promoter variant links CNR1 gene expression to HDL cholesterol level

Activation of the central nervous system induced by micro-magnetic stimulation

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

Select interneuron clusters determine female sexual receptivity in Drosophila

Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum

Transferring a synthetic gene circuit from yeast to mammalian cells

Structural modulation of gut microbiota in life-long calorie-restricted mice

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

Plasmon transport in graphene investigated by time-resolved electrical measurements

Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis

In-gap quasiparticle excitations induced by non-magnetic Cu impurities in Na(Fe0.96Co0.03Cu0.01)As revealed by scanning tunnelling spectroscopy

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum

Identifying sources of tick blood meals using unidentified tandem mass spectral libraries

Hypervalent surface interactions for colloidal stability and doping of silicon nanocrystals

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop

Higher levels of multiple ecosystem services are found in forests with more tree species

Control of synaptic vesicle endocytosis by an extracellular signalling molecule

Relativistic electron mirrors from nanoscale foils for coherent frequency upshift to the extreme ultraviolet

The Capsaspora genome reveals a complex unicellular prehistory of animals

Group A PP2Cs evolved in land plants as key regulators of intrinsic desiccation tolerance

Dimensionality of brain networks linked to life-long individual differences in self-control

Resonant tunnelling and negative differential conductance in graphene transistors

Strain-controlled magnetic domain wall propagation in hybrid piezoelectric/ferromagnetic structures

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

An engineered dimeric protein pore that spans adjacent lipid bilayers

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Optical control of hard X-ray polarization by electron injection in a laser wakefield accelerator

Mechanism of Tetracycline Resistance by Ribosomal Protection Protein Tet(O)

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

Susceptibility of memory consolidation during lapses in recall

Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

A protective layer approach to solvatochromic sensors

Erratum: Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomers

Quantum coherence controls the charge separation in a prototypical artificial light-harvesting system

Non-Darwinian dynamics in therapy-induced cancer drug resistance

Genomic deletions disrupt nitrogen metabolism pathways of a cyanobacterial diatomsymbiont

p53 Regulates Period2 Expression and the Circadian Clock

Functional salivary gland regeneration by transplantation of a bioengineered organ germ

Orai1-dependent Calcium Entry Promotes Skeletal Muscle Growth and Limits Fatigue

Human gut microbiota community structures in urban and rural populations in Russia

Molecular switches from benzene derivatives adsorbed on metal surfaces

A nonspecific defensive compound evolves into a competition avoidance cue and a female sex pheromone

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

Quantum dot imaging platform for single-cell molecular profiling

Selective isolation of gold facilitated by second-sphere coordination with α-cyclodextrin

Controlling the influence of Auger recombination on the performance of quantum-dot light-emitting diodes

Prothymosin α overexpression contributes to the development of pulmonary emphysema

Brownian motion and quantum dynamics of magnetic monopoles in spin ice

Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites

Mechanisms of molecular transport through the urea channel of Helicobacter pylori

Bio-Inspired Voltage-Dependent Calcium Channel Blockers

Metformin improves healthspan and lifespan in mice

Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region

Erratum: Reinforcement learning in professional basketball players

Heterozygous mutations in PALB2 cause DNA replication and damage response defects

HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

Erratum: Laminin E8 fragments support efficient adhesion and expansion of dissociated humanpluripotent stem cells

The transcriptional repressor NKAP is required for the development of iNKT cells

A safe lithium mimetic for bipolar disorder

Pericyte loss influences Alzheimer-like neurodegeneration in mice

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

The microbiome extends to subepidermal compartments of normal skin

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension

Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development

Development of Middle Stone Age innovation linked to rapid climate change

Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor

Autonomous Vascular Networks Synchronize GABA Neuron Migration in the Embryonic Forebrain

A Genome-wide Regulatory Network Identifies Key Transcription Factors for Memory CD8+ T Cell Development

Intrinsic electrical conductivity of nanostructured metal-organic polymer chains

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

Ray-optics cloaking devices for large objects in incoherent natural light

RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue

Evaluating cell lines as tumour models by comparison of genomic profiles

Semiconductor-based DNA sequencing of histone modification states

Integrated spatial multiplexing of heralded single-photon sources

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

A subset of Drosophila Myc sites remain associated with mitotic chromosomes co-localized with insulator proteins

Cytotoxicity of Botulinum Neurotoxins Reveals a Direct Role of Syntaxin 1 and SNAP-25 in Neuron Survival

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

Endonuclease V cleaves at inosines in RNA

Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations

Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress

Draft genome sequence of the mulberry tree Morus notabilis

Year: 2012, Volume: 3

Year: 2011, Volume: 2

Year: 2010, Volume: 1

Non-Uniform Membrane Diffusion Enables Steady-State Cell Polarization via Vesicular Trafficking

Content Provider	PubMed Central
Author	Slaughter, Brian D. Unruh, Jay R. Das, Arupratan Smith, Sarah E. Rubinstein, Boris Rong, Li
Abstract	Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar plasma membrane, with sites of exocytosis correlating with microdomains of higher concentration and slower diffusion of Cdc42 compared to surrounding regions. Numerical simulations using experimentally obtained diffusion coefficients and trafficking geometry revealed that non-uniform membrane diffusion of Cdc42 in fact enables temporally sustained cell polarity. We show further that phosphatidylserine (PS), a phospholipid recently found to be crucial for cell polarity, is enriched in Cdc42 microdomains and weakening a potential interaction between PS and Cdc42 enhanced Cdc42 diffusion in the microdomains but impeded the strength of polarization. These findings demonstrate a critical role for membrane microdomains in vesicular trafficking mediated cell polarity.
Related Links	http://dx.doi.org/10.1038/ncomms2370
Ending Page	1380
Page Count	1
Starting Page	1380
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature communications
Volume Number	4
Language	English
Publisher Date	2013-01-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in