NDLI: Effects of Extrinsic Mortality on the Evolution of Aging: A Stochastic Modeling Approach

Content Provider	PubMed Central
Author	Shokhirev, Maxim Nikolaievich Johnson, Adiv Adam
Editor	Flatt, Thomas
Copyright Year	2014
Abstract	The evolutionary theories of aging are useful for gaining insights into the complex mechanisms underlying senescence. Classical theories argue that high levels of extrinsic mortality should select for the evolution of shorter lifespans and earlier peak fertility. Non-classical theories, in contrast, posit that an increase in extrinsic mortality could select for the evolution of longer lifespans. Although numerous studies support the classical paradigm, recent data challenge classical predictions, finding that high extrinsic mortality can select for the evolution of longer lifespans. To further elucidate the role of extrinsic mortality in the evolution of aging, we implemented a stochastic, agent-based, computational model. We used a simulated annealing optimization approach to predict which model parameters predispose populations to evolve longer or shorter lifespans in response to increased levels of predation. We report that longer lifespans evolved in the presence of rising predation if the cost of mating is relatively high and if energy is available in excess. Conversely, we found that dramatically shorter lifespans evolved when mating costs were relatively low and food was relatively scarce. We also analyzed the effects of increased predation on various parameters related to density dependence and energy allocation. Longer and shorter lifespans were accompanied by increased and decreased investments of energy into somatic maintenance, respectively. Similarly, earlier and later maturation ages were accompanied by increased and decreased energetic investments into early fecundity, respectively. Higher predation significantly decreased the total population size, enlarged the shared resource pool, and redistributed energy reserves for mature individuals. These results both corroborate and refine classical predictions, demonstrating a population-level trade-off between longevity and fecundity and identifying conditions that produce both classical and non-classical lifespan effects.
Related Links	http://dx.doi.org/10.1371/journal.pone.0086602
Starting Page	86602
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	1
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Quantifying Intrinsic and Extrinsic Variability in Stochastic Gene Expression Models

Modeling Effects of RNA on Capsid Assembly Pathways via Coarse-Grained Stochastic Simulation

Evolution with Stochastic Fitness and Stochastic Migration

The Effects of Aging on Conflict Detection

STOCHASTIC MODEL FOR ANALYSIS OF LONGITUDINAL DATA ON AGING AND MORTALITY

Structured Modeling and Analysis of Stochastic Epidemics with Immigration and Demographic Effects

Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation

The Effects of Aging on Researchers' Publication and Citation Patterns

Aging Worsens the Effects of Sleep Deprivation on Postural Control

Effects of Extrinsic Mortality on the Evolution of Aging: A Stochastic Modeling Approach

Similar Documents

Quantifying Intrinsic and Extrinsic Variability in Stochastic Gene Expression Models

Modeling Effects of RNA on Capsid Assembly Pathways via Coarse-Grained Stochastic Simulation

Evolution with Stochastic Fitness and Stochastic Migration

The Effects of Aging on Conflict Detection

STOCHASTIC MODEL FOR ANALYSIS OF LONGITUDINAL DATA ON AGING AND MORTALITY

Structured Modeling and Analysis of Stochastic Epidemics with Immigration and Demographic Effects

Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation

The Effects of Aging on Researchers' Publication and Citation Patterns

Aging Worsens the Effects of Sleep Deprivation on Postural Control

Effects of Extrinsic Mortality on the Evolution of Aging: A Stochastic Modeling Approach