NDLI: Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells

Content Provider	PubMed Central
Author	Feng, Shengmei Cai, Ming Liu, Pengcheng Wei, Li Wang, Jinshen Qi, Jin Deng, Lianfu
Editor	Rameshwar, Pranela
Copyright Year	2014
Abstract	Previous studies have shown that the rate of breast cancer metastasis correlates with the expression of vacuolar H+-ATPases (V-ATPases). However, how V-ATPase is involved in breast cancer metastasis remains unknown. Our previous study showed that Atp6v1c1-depleted osteoclasts did not form organized actin rings and that Atp6v1c1 co-localizes with F-actin. In this study, we found that the normal arrangement of filamentous actin is disrupted in Atp6v1c1-depleted 4T1 mouse breast cancer cells and in the ATP6V1C1-depleted human breast cancer cell lines MDA-MB-231 and MDA-MB-435s. We further found that Atp6v1c1 co-localizes with F-actin in 4T1 cells. The results of our study suggest that high expression of Atp6v1c1 affects the actin structure of cancer cells such that it facilitates breast cancer metastasis. The findings also indicate that Atp6v1c1 could be a novel target for breast cancer metastasis therapy.
Related Links	http://dx.doi.org/10.1371/journal.pone.0084833
Starting Page	84833
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	1
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction: Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

Actin Filament Attachments for Sustained Motility In Vitro Are Maintained by Filament Bundling

Src Kinases Regulate De Novo Actin Polymerization during Exocytosis in Neuroendocrine Chromaffin Cells

TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells

Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

Tetraspanin CD9 Regulates Cell Contraction and Actin Arrangement via RhoA in Human Vascular Smooth Muscle Cells

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Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells

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Correction: Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

Actin Filament Attachments for Sustained Motility In Vitro Are Maintained by Filament Bundling

Src Kinases Regulate De Novo Actin Polymerization during Exocytosis in Neuroendocrine Chromaffin Cells

TFPI Alpha and Beta Regulate mRNAs and microRNAs Involved in Cancer Biology and in the Immune System in Breast Cancer Cells

Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

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Stress Generation and Filament Turnover during Actin Ring Constriction

Spontaneous Structural Changes in Actin Regulate G-F Transformation

Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells