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Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition
| Content Provider | PubMed Central |
|---|---|
| Author | Long, Eric O. Kim, Hun Sik Liu, Dongfang Peterson, Mary E. Rajagopalan, Sumati |
| Copyright Year | 2013 |
| Abstract | Understanding how signals are integrated to control NK cell responsiveness in the absence of antigen-specific receptors has been a challenge, but recent work has revealed some underlying principles that govern NK cell responses. NK cells use an array of innate receptors to sense their environment and respond to alterations caused by infections, cellular stress and transformation. No single activation receptor dominates; instead, synergistic signals from combinations of receptors are integrated to activate natural cytotoxicity and cytokine production. Inhibitory receptors for MHC class I have a critical role in controlling NK cell responses and paradoxically, in maintaining NK cells in a state of responsiveness to subsequent activation events, a process referred to as licensing. MHC-I specific inhibitory receptors both block activation signals and trigger signals to phosphorylate and inactivate the small adaptor Crk. These different facets of inhibitory signaling are incorporated into a revocable license model for the reversible tuning of NK cell responsiveness. |
| Related Links | http://dx.doi.org/10.1146/annurev-immunol-020711-075005 |
| File Format | |
| ISSN | 15453278 |
| e-ISSN | 15453278 |
| Journal | Annual review of immunology |
| Volume Number | 31 |
| Language | English |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
