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| Content Provider | PubMed Central |
|---|---|
| Author | Su, Zhenbi Tan, Wei Robin, Shandas Hunter, Kendall S. |
| Copyright Year | 2013 |
| Abstract | We develop a simple computational model based on measurements from a hypoxic neonatal calf model of pulmonary hypertension (PH) to investigate the interplay between vascular and ventricular measures in the setting of progressive PH. Model parameters were obtained directly from in vivo and ex vivo measurements of neonatal calves. Seventeen sets of model-predicted impedance and mean pulmonary arterial pressure (mPAP) show good agreement with the animal measurements, thereby validating the model. Next, we considered a predictive model in which three parameters, PVR, elastic modulus (EM), and arterial thickness, were varied singly from one simulation to the next to study their individual roles in PH progression. Finally, we used the model to predict the individual impacts of clinical (vasodilatory) and theoretical (compliance increasing) PH treatments on improving pulmonary hemodynamics. Our model (1) displayed excellent patient-specific agreement with measured global pulmonary parameters; (2) quantified relationships between PVR and mean pressure and PVS and pulse pressure, as well as studiying the right ventricular (RV) afterload, which could be measured as a hydraulic load calculated from spectral analysis of pulmonary artery pressure and flow waves; (3) qualitatively confirmed the derangement of vascular wall shear stress in progressive PH; and (4) established that decreasing proximal vascular stiffness through a theoretical treatment of reversing proximal vascular remodeling could decrease RV afterload. |
| Related Links | http://dx.doi.org/10.1155/2013/618326 |
| Starting Page | 618326 |
| File Format | |
| ISSN | 1748670X |
| e-ISSN | 17486718 |
| Journal | Computational and Mathematical Methods in Medicine |
| Volume Number | 2013 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Modelling and Simulation Immunology and Microbiology(all) Applied Mathematics Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Modeling and Simulation |
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