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| Content Provider | PubMed Central |
|---|---|
| Author | Petro, Julkunen Wilson, Wouter Isaksson, Hanna Jurvelin, Jukka S. Herzog, Walter Korhonen, Rami K. |
| Copyright Year | 2013 |
| Abstract | The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e.g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition. In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level. We concentrate on the use of fibril-reinforced models of cartilage. Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach. At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation. |
| Related Links | http://dx.doi.org/10.1155/2013/326150 |
| Starting Page | 326150 |
| File Format | |
| ISSN | 17486718 |
| e-ISSN | 17486718 |
| Journal | Computational and Mathematical Methods in Medicine |
| Volume Number | 2013 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Modeling and Simulation |
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