Loading...
Please wait, while we are loading the content...
Similar Documents
Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation
| Content Provider | PubMed Central |
|---|---|
| Author | Davies, Luke C. Rosas, Marcela Jenkins, Stephen J. Liao, Chia-te Scurr, Martin J. Frank, Brombacher Fraser, Donald J. Allen, Judith E. Jones, Simon A. Taylor, Philip R. |
| Abstract | The general paradigm is that monocytes are recruited to sites of inflammation and terminally-differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated. |
| Related Links | http://dx.doi.org/10.1038/ncomms2877 |
| File Format | |
| ISSN | 20411723 |
| e-ISSN | 20411723 |
| Journal | Nature communications |
| Volume Number | 4 |
| Language | English |
| Publisher Date | 2013-05-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology |
