NDLI: Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

Content Provider	PubMed Central
Author	Sieger, Tomáš Bonnet, Cecilia Serranová, Tereza Wild, Jiří Novák, Daniel Růžička, Filip Dušan, Urgošík Růžička, Evžen Gaymard, Bertrand Jech, Robert
Editor	Hou, Bing
Copyright Year	2013
Abstract	The oculomotor role of the basal ganglia has been supported by extensive evidence, although their role in scanning eye movements is poorly understood. Nineteen Parkinsońs disease patients, which underwent implantation of deep brain stimulation electrodes, were investigated with simultaneous intraoperative microelectrode recordings and single channel electrooculography in a scanning eye movement task by viewing a series of colored pictures selected from the International Affective Picture System. Four patients additionally underwent a visually guided saccade task. Microelectrode recordings were analyzed selectively from the subthalamic nucleus, substantia nigra pars reticulata and from the globus pallidus by the WaveClus program which allowed for detection and sorting of individual neurons. The relationship between neuronal firing rate and eye movements was studied by crosscorrelation analysis. Out of 183 neurons that were detected, 130 were found in the subthalamic nucleus, 30 in the substantia nigra and 23 in the globus pallidus. Twenty percent of the neurons in each of these structures showed eye movement-related activity. Neurons related to scanning eye movements were mostly unrelated to the visually guided saccades. We conclude that a relatively large number of basal ganglia neurons are involved in eye motion control. Surprisingly, neurons related to scanning eye movements differed from neurons activated during saccades suggesting functional specialization and segregation of both systems for eye movement control.
Related Links	http://dx.doi.org/10.1371/journal.pone.0078581
Starting Page	78581
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	11
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-11-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease

Covert Anti-Compensatory Quick Eye Movements during Head Impulses

Intersegmental Eye-Head-Body Interactions during Complex Whole Body Movements

In Pursuit of Delay-Related Brain Activity for Anticipatory Eye Movements

Common Features of Neural Activity during Singing and Sleep Periods in a Basal Ganglia Nucleus Critical for Vocal Learning in a Juvenile Songbird

Correction: Intersegmental Eye-Head-Body Interactions during Complex Whole Body Movements

Eye Movements Reveal Effects of Visual Content on Eye Guidance and Lexical Access during Reading

Correction: In Pursuit of Delay-Related Brain Activity for Anticipatory Eye Movements

Eye Movements Predict Recollective Experience

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease

Similar Documents

Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson’s Disease

Covert Anti-Compensatory Quick Eye Movements during Head Impulses

Intersegmental Eye-Head-Body Interactions during Complex Whole Body Movements

In Pursuit of Delay-Related Brain Activity for Anticipatory Eye Movements

Common Features of Neural Activity during Singing and Sleep Periods in a Basal Ganglia Nucleus Critical for Vocal Learning in a Juvenile Songbird

Correction: Intersegmental Eye-Head-Body Interactions during Complex Whole Body Movements

Eye Movements Reveal Effects of Visual Content on Eye Guidance and Lexical Access during Reading

Correction: In Pursuit of Delay-Related Brain Activity for Anticipatory Eye Movements

Eye Movements Predict Recollective Experience

Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson’s Disease