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| Content Provider | PubMed Central |
|---|---|
| Author | Wiegant, F. A. C. Poot, S. A. H. De Boers-trilles, V. E. Schreij, A. M. A |
| Copyright Year | 2013 |
| Abstract | In contrast to the detrimental action of severe stress conditions, the beneficial effects of mild stress, known as hormesis, is increasingly discussed and studied. A variety of applications for hormesis in risk assessment processes, anti-ageing strategies and clinical therapies have been proposed. The molecular mechanisms underlying the phenomenon of hormesis, however, are not yet fully understood. A possible mechanism that has been proposed for hormesis, the homoeostasis overshoot hypothesis, assumes that an overshoot of repair- and self-recovery mechanisms in response to mild damage can be held responsible for the beneficial effects of hormesis. The present paper proposes ‘cellular quality control’ as a further explanation of the molecular mechanisms underlying the benefits observed after exposure to mild stress. The most important quality control mechanisms are outlined and their known and hypothesised actions in hormesis are discussed. As an example, different aspects of protein quality control will be described in more detail, which includes the reaction of the cell upon stress-induced protein damage and –aggregation. The regulation of Heat Shock Proteins and components from the ubiquitin proteasome system as part of cellular quality control is described in relation to its beneficial role in hormesis. |
| Related Links | http://dx.doi.org/10.2203/dose-response.12-030.wiegant |
| Ending Page | 430 |
| Page Count | 18 |
| Starting Page | 413 |
| File Format | |
| ISSN | 15593258 |
| e-ISSN | 15593258 |
| Journal | Dose-Response |
| Issue Number | 3 |
| Volume Number | 11 |
| Language | English |
| Publisher | International Hormesis Society |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | International Hormesis Society |
| Subject Keyword | Toxicology Public Health, Environmental and Occupational Health Health, Toxicology and Mutagenesis Chemical Health and Safety Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Chemical Health and Safety |
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