NDLI: Epidemiological Evidence for Possible Radiation Hormesis from Radon Exposure: A Case-Control Study Conducted in Worcester, MA.

Content Provider	PubMed Central
Author	Thompson, Richard E.
Abstract	Data from a case-control study of lung cancer and residential radon exposure conducted in Worcester County, Massachusetts, are presented. Lung cancer risk was estimated using conditional logistic regression models that controlled for demographic, smoking, and occupational exposure covariates. Preliminary exploratory analyses using lowess smoothing revealed a non-linear association between exposure and the log odds of lung cancer. Radon exposure was considered by using linear spline terms in order to model this nonlinearity. The best fit of this linear spline model to these data predicted a shift from a positive to a negative slope in the log-odds of lung cancer at a radon concentration of 70 Bq m−3. A statistically significant decrease in cancer risk with increased exposure was found for values ≤ 157 Bq m−3 normalized to the reference exposure of 4.4 Bq m−3, the lowest radon concentration measured(adjusted odds ratio (AOR) [95% CI] = 0.42 [0.180, 1.00], p = 0.049). This result is consistent with those reported elsewhere that considered radon exposure with cubic spline terms (Thompson, RE et al. 2008). Furthermore, this model predicts an AOR that is numerically less than 1.0 for radon exposures up to 545 Bq m−3 versus the above baseline, reference exposure.
Related Links	http://dx.doi.org/10.2203/dose-response.10-026.thompson
Ending Page	75
Page Count	17
Starting Page	59
File Format	PDF
ISSN	15593258
e-ISSN	15593258
Journal	Dose-Response
Issue Number	1
Volume Number	9
Language	English
Publisher	International Hormesis Society
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	International Hormesis Society
Subject Keyword	Toxicology Public Health, Environmental and Occupational Health Health, Toxicology and Mutagenesis Chemical Health and Safety Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Chemical Health and Safety

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Epidemiological Evidence for Possible Radiation Hormesis from Radon Exposure: A Case-Control Study Conducted in Worcester, MA.

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