NDLI: cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

Content Provider	PubMed Central
Author	Tao, Yijin Pan, Miaozhen Liu, Shufeng Fang, Fang Lu, Runxia Lu, Chanyi Zheng, Min An, Jianhong Xu, Hongjia Zhao, Fuxin Chen, Jiang-fan Jia, Qu Zhou, Xiangtian
Editor	Trackman, Philip C.
Copyright Year	2013
Abstract	The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP). We investigated the associations between cAMP, myopia development in guinea pigs, and collagen synthesis by human scleral fibroblasts (HSFs). Form-deprived myopia (FDM) was induced by unilateral masking of guinea pig eyes. Scleral cAMP levels increased selectively in the FDM eyes and returned to normal levels after unmasking and recovery. Unilateral subconjunctival treatment with the adenylyl cyclase (AC) activator forskolin resulted in a myopic shift accompanied by reduced collagen mRNA levels, but it did not affect retinal electroretinograms. The AC inhibitor SQ22536 attenuated the progression of FDM. Moreover, forskolin inhibited collagen mRNA levels and collagen secretion by HSFs. The inhibition was reversed by SQ22536. These results demonstrate a critical role of cAMP in control of myopia development. Selective regulation of cAMP to control scleral collagen synthesis may be a novel therapeutic strategy for preventing and treating myopia.
Related Links	http://dx.doi.org/10.1371/journal.pone.0071441
Starting Page	71441
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	8
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-08-12
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia (2013)

The collagen metabolism affects the scleral mechanical properties in the different processes of scleral remodeling

Shaping Eyeballs by Scleral Collagen Cross-Linking: A Hypothesis for Myopia Treatment

Scleral remodeling in myopia development

BMP-2 Is Involved in Scleral Remodeling in Myopia Development

4] "the zebra system" user guide --- cern program library writeups, q100/q101 (1995).

Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia.

Structural and ultrastructural changes to the sclera in a mammalian model of high myopia.

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

Similar Documents

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia (2013)

The collagen metabolism affects the scleral mechanical properties in the different processes of scleral remodeling

Shaping Eyeballs by Scleral Collagen Cross-Linking: A Hypothesis for Myopia Treatment

Scleral remodeling in myopia development

BMP-2 Is Involved in Scleral Remodeling in Myopia Development

4] "the zebra system" user guide --- cern program library writeups, q100/q101 (1995).

Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia.

Structural and ultrastructural changes to the sclera in a mammalian model of high myopia.

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia