NDLI: SARM is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

Content Provider	PubMed Central
Author	Hou, Ying-ju Banerjee, Rebecca Thomas, Bobby Nathan, Carl Adolfo, García-sastre Ding, Aihao Uccellini, Melissa B.
Abstract	Four of the five members of the Toll-interleukin-1 receptor (TIR) domain-containing adaptor family are required for signaling downstream of Toll-like receptors, promoting innate immune responses against different pathogens. However, the role of the fifth member of this family, sterile alpha and TIR-domain containing 1 (SARM), is unclear. SARM is expressed primarily in the central nervous system where it is required for axonal death. Studies in C.elegans have also shown a role for SARM in innate immunity. To clarify the role of mammalian SARM in innate immunity, we infected SARM−/− mice with a number of bacterial and viral pathogens. SARM−/− mice show normal responses to Listeria monocytogenes, Mycobacterium tuberculosis (Mtb), and influenza virus, but show dramatic protection from death after CNS infection with vesicular stomatitis virus (VSV). Protection correlates with reduced CNS injury and cytokine production by non-hematopoietic cells, suggesting that SARM is a positive regulator of cytokine production. Neurons and microglia are the predominant source of cytokines in vivo, supporting a role for SARM as a link between neuronal injury and innate immunity.
Related Links	http://dx.doi.org/10.4049/jimmunol.1300374
Ending Page	883
Page Count	9
Starting Page	875
File Format	PDF
ISSN	15506606
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	2
Volume Number	191
Language	English
Publisher Date	2013-07-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die – that is the question

Chronic Viral Infection and Primary Central Nervous System Malignancy

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

Viral Infection Triggers Central Nervous System Autoimmunity Via Activation of Dual TCR-Expressing CD8+ T Cells

Chronic Viral Infection and Primary Central Nervous System Malignancy

Long-Term Persistence of Activated Cytotoxic T Lymphocytes after Viral Infection of the Central Nervous System

Pre‐existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development

SARM is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

Similar Documents

SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die – that is the question

Chronic Viral Infection and Primary Central Nervous System Malignancy

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

Viral Infection Triggers Central Nervous System Autoimmunity Via Activation of Dual TCR-Expressing CD8+ T Cells

Chronic Viral Infection and Primary Central Nervous System Malignancy

Long-Term Persistence of Activated Cytotoxic T Lymphocytes after Viral Infection of the Central Nervous System

Pre‐existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development

SARM is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection