NDLI: Model-Based Simulation and Prediction of an Antiviral Strategy against Influenza A Infection

Content Provider	PubMed Central
Author	Hur, Kye-yeon Moon, Joon-young Kim, Seung-hwan Yoo, Joo-yeon
Editor	Jodie, Mcvernon
Copyright Year	2013
Abstract	There is a strong need to develop novel strategies in using antiviral agents to efficiently treat influenza infections. Thus, we constructed a rule-based mathematical model that reflects the complicated interactions of the host immunity and viral life cycle and analyzed the key controlling steps of influenza infections. The main characteristics of the pandemic and seasonal influenza strains were estimated using parameter values derived from cells infected with Influenza A/California/04/2009 and Influenza A/NewCaledonia/20/99, respectively. The quantitative dynamics of the infected host cells revealed a more aggressive progression of the pandemic strain than the seasonal strain. The perturbation of each parameter in the model was then tested for its effects on viral production. In both the seasonal and pandemic strains, the inhibition of the viral release (kC ), the reinforcement of viral attachment (kV ), and an increased transition rate of infected cells into activated cells (kI ) exhibited significant suppression effects on the viral production; however, these inhibitory effects were only observed when the numerical perturbations were performed at the early stages of the infection. In contrast, combinatorial perturbations of both the inhibition of viral release and either the reinforcement of the activation of infected cells or the viral attachment exhibited a significant reduction in the viral production even at a later stage of infection. These results suggest that, in addition to blocking the viral release, a combination therapy that also enhances either the viral attachment or the transition of the infected cells might provide an alternative for effectively controlling progressed influenza infection.
Related Links	http://dx.doi.org/10.1371/journal.pone.0068235
Starting Page	68235
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-07-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza

Protocatechuic Acid, a Novel Active Substance against Avian Influenza Virus H9N2 Infection

Diagnosis and Antiviral Intervention Strategies for Mitigating an Influenza Epidemic

Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro

An Economic Analysis of Strategies to Control Clostridium Difficile Transmission and Infection Using an Agent-Based Simulation Model

The Effect of Rosuvastatin in a Murine Model of Influenza A Infection

Partial and Full PCR-Based Reverse Genetics Strategy for Influenza Viruses

A Biological Model for Influenza Transmission: Pandemic Planning Implications of Asymptomatic Infection and Immunity

Can Antiviral Drugs Contain Pandemic Influenza Transmission?

Model-Based Simulation and Prediction of an Antiviral Strategy against Influenza A Infection

Similar Documents

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza

Protocatechuic Acid, a Novel Active Substance against Avian Influenza Virus H9N2 Infection

Diagnosis and Antiviral Intervention Strategies for Mitigating an Influenza Epidemic

Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro

An Economic Analysis of Strategies to Control Clostridium Difficile Transmission and Infection Using an Agent-Based Simulation Model

The Effect of Rosuvastatin in a Murine Model of Influenza A Infection

Partial and Full PCR-Based Reverse Genetics Strategy for Influenza Viruses

A Biological Model for Influenza Transmission: Pandemic Planning Implications of Asymptomatic Infection and Immunity

Can Antiviral Drugs Contain Pandemic Influenza Transmission?

Model-Based Simulation and Prediction of an Antiviral Strategy against Influenza A Infection