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| Content Provider | PubMed Central |
|---|---|
| Author | Sahreen, Sumaira Khan, Muhammad Rashid Khan, Rahmat Ali |
| Copyright Year | 2013 |
| Abstract | Effect of methanolic extract of Rumex hastatus roots (MRR) and its derived fractions, n-hexane (HRR), ethyl acetate (ERR), chloroform (CRR), butanol (BRR), and aqueous extract (ARR), was studied against carbon tetrachloride (CCl4) induced hepato and testicular toxicity in rats. Intraperitoneal dose of 20 percent CCl4 (0.5 ml/kg bw) was administered twice a week for eight weeks to a group of rats. Other groups were given CCl4 and various fractions of R. hastatus roots (200 mg/kg bw). CCl4 treatment depleted glutathione contents and activities of antioxidant enzymes while increased the concentration of lipid peroxides (TBARS) along with corresponding DNA injuries and histopathological damages. Supplementation with various fractions of R. hastatus roots (200 mg/kg body weight) attenuated the toxicity of CCl4 in liver and testis tissues through improvement in the serological, enzymatic, and histological parameters towards the normal. Posttreatment of R. hastatus roots (200 mg/kg body weight) also reversed the alteration in reproductive hormonal secretions and DNA damages in CCl4 treated rats. The results clearly demonstrated that R. hastatus treatment augments the antioxidants defense mechanism and provides the evidence that it may have a therapeutic role in free radical mediated diseases. |
| Related Links | http://dx.doi.org/10.1155/2013/325406 |
| Starting Page | 325406 |
| File Format | |
| ISSN | 19420900 |
| e-ISSN | 19420994 |
| Journal | Oxidative Medicine and Cellular Longevity |
| Volume Number | 2013 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Cell Biology Biochemistry Ageing Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Aging Medicine Biochemistry |
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