NDLI: Two regulatory domains flank the mouse H19 gene.

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Posttranscriptional regulation of cytochrome c expression during the developmental cycle of Trypanosoma brucei.

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Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae.

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DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

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A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.

Two regulatory domains flank the mouse H19 gene.

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Sex-specific control of Drosophila melanogaster yolk protein 1 gene expression is limited to transcription.

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Localization and expression of mRNA for a macronuclear-specific histone H2A variant (hv1) during the cell cycle and conjugation of Tetrahymena thermophila.

Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins.

Gene dosage alteration of L2 ribosomal protein genes in Saccharomyces cerevisiae: effects on ribosome synthesis.

Concentration dependence of transcriptional transactivation in inducible E1A-containing human cells.

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function.

Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.

Rapid transcriptional regulation by phytochrome of the genes for phytochrome and chlorophyll a/b-binding protein in Avena sativa.

Interactions between the promoter and first intron are involved in transcriptional control of alpha 1(I) collagen gene expression.

Regulation of Rous sarcoma virus RNA splicing and stability.

Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts.

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

Organization of the Ly-5 gene.

c-kit protein, a transmembrane kinase: identification in tissues and characterization.

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Developmental programs of human erythroleukemia cells: globin gene expression and methylation.

Organization of replication of ribosomal DNA in Saccharomyces cerevisiae.

Copy number and partition of the Saccharomyces cerevisiae 2 micron plasmid controlled by transcription regulators.

The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity.

Positional and developmental regulation of glutamine synthetase expression in mouse liver.

Purified mu EBP-E binds to immunoglobulin enhancers and promoters.

Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II.

GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae.

Multiple subelements within the polyomavirus enhancer function synergistically to activate DNA replication.

Gene expression of human DNA polymerase alpha during cell proliferation and the cell cycle.

Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.

Expression and processing of a recombinant human macrophage colony-stimulating factor in mouse cells.

Constitutive binding of yeast heat shock factor to DNA in vivo.

Reproducible and variable rearrangements of a Tetrahymena thermophila surface protein gene family occur during macronuclear development.

A silencer element from the alpha-globin gene inhibits expression of beta-like genes.

Platelet-derived growth factor does not induce c-fos in NIH 3T3 cells expressing the EJ-ras oncogene.

Effect of sequence differences between somatic and oocyte 5S RNA genes on transcriptional efficiency in an oocyte S150 extract.

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Two regulatory domains flank the mouse H19 gene.

Content Provider	PubMed Central
Author	Yoo-warren, H. Ingram, R. S. Tilghman, S. M. Pachnis, V.
Abstract	The mouse H19 gene was identified by virtue of its coordinate regulation with the mouse alpha-fetoprotein gene. Both genes are expressed in the fetal liver, gut, and visceral endoderm of the yolk sac and are repressed shortly after birth in the liver and gut. They are both under the control of two trans-acting loci: raf, which affects the adult basal levels of the two mRNAs, and Rif, which affects their inducibility during liver regeneration. One crucial difference between the two genes is the activation of the H19 gene in mesoderm derivatives, skeletal and cardiac muscle. As a strategy for explaining both the similarities and differences in their modes of expression, the regulatory domains responsible for the expression of the H19 gene in liver were identified by transiently introducing the gene into a human hepatoma cell line. Two regions necessary for high-level expression of the gene could be identified, a promoter-proximal domain immediately preceding the start of transcription and an enhancer domain which lies between 5 and 6.5 kilobases 3' of the polyadenylation site. The 3' domain consists of two separable enhancer elements, each of which exhibits the properties of tissue-specific enhancers. Nucleotide sequence comparisons between the two H19 and three alpha-fetoprotein enhancers revealed limited similarities which are candidates for binding of common regulatory factors. Sequences which lie 3' of the gene are also required for the expression of the H19 gene following differentiation of teratocarcinoma cells into visceral endoderm.
Starting Page	4707
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	11
Volume Number	8
Language	English
Publisher Date	1988-11-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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