NDLI: Interleukin-10 restricts memory T cell inflation during cytomegalovirus infection

Content Provider	PubMed Central
Author	Jones, Morgan Ladell, Kristin Wynn, Katherine K. Stacey, Maria A. Quigley, MÃ¡ire F. Gostick, Emma Price, David A. Humphreys, Ian R.
Abstract	The beta-herpesvirus cytomegalovirus induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. Here, we report that this expansion, or “inflation”, of memory T cells is amplified dramatically during mouse cytomegalovirus (MCMV) infection of interleukin-10 (IL-10) knockout (IL-10−/−) mice. T cells from IL-10−/− mice were oligoclonal, exhibited a highly activated phenotype, expressed antiviral cytokines and degranulated in response to cognate antigen encounter ex vivo. Moreover, latent viral load was reduced in IL-10−/− mice. Importantly, these results were recapitulated by IL-10 receptor blockade during chronic/latent infection of wild-type mice. These data demonstrate that regulatory immune mechanisms can influence cytomegalovirus-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses.
Related Links	http://dx.doi.org/10.4049/jimmunol.1001535
Ending Page	3592
Page Count	10
Starting Page	3583
File Format	PDF
ISSN	15506606
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	6
Volume Number	185
Language	English
Publisher Date	2010-09-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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