NDLI: Complex regulation of heat shock- and glucose-responsive genes in human cells.

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Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species.

Effect of protein synthesis inhibition on gene expression during early development of Dictyostelium discoideum.

Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.

Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

Both upstream and intron sequence elements are required for elevated expression of the rat somatic cytochrome c gene in COS-1 cells.

Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region.

An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations.

The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.

DNase I- and micrococcal nuclease-hypersensitive sites in the human apolipoprotein B gene are tissue specific.

The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites.

Effect of heat shock on ribosome synthesis in Drosophila melanogaster.

Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene.

DNA affinity labeling of adenovirus type 2 upstream promoter sequence-binding factors identifies two distinct proteins.

The site-specific ribosomal DNA insertion element R1Bm belongs to a class of non-long-terminal-repeat retrotransposons.

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Transformation by the src oncogene alters glucose transport into rat and chicken cells by different mechanisms.

Identification and characterization of two functional domains within the murine heavy-chain enhancer.

A developmentally regulated membrane protein gene in Dictyostelium discoideum is also induced by heat shock and cold shock.

Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.

The accumulation of three yeast ribosomal proteins under conditions of excess mRNA is determined primarily by fast protein decay.

Tyrosine phosphorylations in vivo associated with v-fms transformation.

Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.

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Regulation of rat liver maturation in vitro by glucocorticoids.

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Sedimentation analysis of polyadenylation-specific complexes.

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Developmentally controlled telomere addition in wild-type and mutant paramecia.

Primary structure of the human fgr proto-oncogene product p55c-fgr.

Identification of the human beta-actin enhancer and its binding factor.

Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.

The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

Differential regulation of the yeast CDC7 gene during mitosis and meiosis.

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

Identification of a DNA segment that is necessary and sufficient for alpha-specific gene control in Saccharomyces cerevisiae: implications for regulation of alpha-specific and a-specific genes.

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function.

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

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Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors.

A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to EIA transactivation.

Saccharomyces cerevisiae SUP53 tRNA gene transcripts are processed by mammalian cell extracts in vitro but are not processed in vivo.

A highly evolutionarily conserved mitochondrial protein is structurally related to the protein encoded by the Escherichia coli groEL gene.

Detection of two tissue-specific DNA-binding proteins with affinity for sites in the mouse beta-globin intervening sequence 2.

Complex regulation of heat shock- and glucose-responsive genes in human cells.

Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells.

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

Human hTM alpha gene: expression in muscle and nonmuscle tissue.

6;7 chromosomal translocation in spontaneously arising rat immunocytomas: evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target.

Production and characterization of biologically active recombinant beta nerve growth factor.

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice.

Evidence that the functional beta-actin gene is single copy in most mice and is associated with 5' sequences capable of conferring serum- and cycloheximide-dependent regulation.

Sequence and expression of a type II keratin, K5, in human epidermal cells.

The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

Developmental expression of two forms of pp60c-src in mouse brain.

SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae.

Transfection of an immunoglobulin kappa gene into mature human B lymphocytes.

Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway

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Complex regulation of heat shock- and glucose-responsive genes in human cells.

Content Provider	PubMed Central
Author	Watowich, S. S. Morimoto, R. I.
Abstract	We have isolated a human genomic clone that encodes the glucose-responsive protein GRP78 and have used this cloned gene probe, together with a cloned HSP70 gene, to study the expression of both stress-induced genes in response to inhibitors of cellular metabolism. On the basis of the effects of this group of chemicals on GRP78 and HSP70 expression, we have identified three classes of stress gene inducers. The first class induces GRP78 expression and includes inhibitors of glycoprotein processing. The second class results in coordinate activation of both GRP78 and HSP70 synthesis and includes amino acid analogs and heavy metals. Chemicals in the third class coordinately induce GRP78 and repress HSP70 expression; this class includes the calcium ionophore A23187 and the glucose analog 2-deoxyglucose. Whereas induction of GRP78 or HSP70 expression is primarily due to transcriptional activation, chemicals that repress HSP70 expression act through posttranscriptional regulation. These results reveal that the regulation of GRP78 and HSP70 expression is complex and may be dependent on the specificity and magnitude of physiological damage.
Starting Page	393
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	1
Volume Number	8
Language	English
Publisher Date	1988-01-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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