NDLI: Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

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Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species.

Effect of protein synthesis inhibition on gene expression during early development of Dictyostelium discoideum.

Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.

Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

Both upstream and intron sequence elements are required for elevated expression of the rat somatic cytochrome c gene in COS-1 cells.

Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region.

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Effect of heat shock on ribosome synthesis in Drosophila melanogaster.

Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene.

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Transformation by the src oncogene alters glucose transport into rat and chicken cells by different mechanisms.

Identification and characterization of two functional domains within the murine heavy-chain enhancer.

A developmentally regulated membrane protein gene in Dictyostelium discoideum is also induced by heat shock and cold shock.

Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.

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Tyrosine phosphorylations in vivo associated with v-fms transformation.

Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.

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Regulation of rat liver maturation in vitro by glucocorticoids.

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Sedimentation analysis of polyadenylation-specific complexes.

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Developmentally controlled telomere addition in wild-type and mutant paramecia.

Primary structure of the human fgr proto-oncogene product p55c-fgr.

Identification of the human beta-actin enhancer and its binding factor.

Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.

The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

Differential regulation of the yeast CDC7 gene during mitosis and meiosis.

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

Identification of a DNA segment that is necessary and sufficient for alpha-specific gene control in Saccharomyces cerevisiae: implications for regulation of alpha-specific and a-specific genes.

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function.

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes.

Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors.

A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to EIA transactivation.

Saccharomyces cerevisiae SUP53 tRNA gene transcripts are processed by mammalian cell extracts in vitro but are not processed in vivo.

A highly evolutionarily conserved mitochondrial protein is structurally related to the protein encoded by the Escherichia coli groEL gene.

Detection of two tissue-specific DNA-binding proteins with affinity for sites in the mouse beta-globin intervening sequence 2.

Complex regulation of heat shock- and glucose-responsive genes in human cells.

Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells.

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

Human hTM alpha gene: expression in muscle and nonmuscle tissue.

6;7 chromosomal translocation in spontaneously arising rat immunocytomas: evidence for c-myc breakpoint clustering and correlation between isotypic expression and the c-myc target.

Production and characterization of biologically active recombinant beta nerve growth factor.

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice.

Evidence that the functional beta-actin gene is single copy in most mice and is associated with 5' sequences capable of conferring serum- and cycloheximide-dependent regulation.

Sequence and expression of a type II keratin, K5, in human epidermal cells.

The cap of both miniexon-derived RNA and mRNA of trypanosomes is 7-methylguanosine.

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

Developmental expression of two forms of pp60c-src in mouse brain.

SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae.

Transfection of an immunoglobulin kappa gene into mature human B lymphocytes.

Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway

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Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

Content Provider	PubMed Central
Author	Carlin, C. R. Simon, D. Mattison, J. Knowles, B. B.
Abstract	Expression of the epidermal growth factor (EGF) was analyzed in six human hepatocellular carcinoma-derived and one human hepatoblastoma-derived cell line, each of which retained the differentiated phenotype and functions of the parenchymal hepatocyte. The level of receptor expression of each hepatoma cell line was similar to that of the normal human fibroblast, approximately 10(5) molecules per cell. However, NPLC/PRF/5, a subline of the PLC/PRF/5 cell line obtained following reestablishment of a xenograft tumor in vitro, was found to express 4 x 10(6) high-affinity EGF receptor molecules per cell. Proliferation of the NPLC/PRF/5 cell line was inhibited in the presence of nanomolar quantities of ligand. Receptor overexpression was found to result from EGF receptor gene amplification without apparent rearrangement of the EGF receptor coding sequences. Although cell-specific variability in posttranslational processing of EGF receptor N-linked oligosaccharides in the hepatoma cell lines was found, no difference between the receptors in PLC/PRF/5 and NPLC/PRF/5 was observed and no aberrant receptor-related species were detected. EGF receptor gene amplification in the NPLC/PRF/5 cell line is probably a reflection of genome instability and selection of variants with augmented growth potential in limiting concentrations of EGF in vivo. When viewed in this light, EGF receptor overexpression could represent a manifestation of tumor progression in the EGF-responsive hepatocyte.
Starting Page	25
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	1
Volume Number	8
Language	English
Publisher Date	1988-01-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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