NDLI: Age-specificity and the evolution of senescence: a discussion

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Age-specificity and the evolution of senescence: a discussion

Content Provider	PubMed Central
Author	Wensink, Maarten
Abstract	Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to the invocation of ‘age-specific’ genes or processes, a concept which is prone to be interpreted too freely. Events do not happen after a certain amount of time has passed. They need initiation, which means that senescence is required to be a continuous process. As a result, a change at a particular age cannot arise in isolation from changes at other ages, in particular not in isolation from changes at the ages nearby. These mechanistic constraints are not without consequence for the patterns of mortality and fecundity that can evolve. I conclude that from purely logical considerations, senescence is characterized as continuous rather than age-specific deterioration. These considerations guide (theoretical) research in the direction of investigating how continuous somatic change arises, rather than focusing at age-specific events.
Related Links	http://dx.doi.org/10.1007/s10522-012-9410-7
Ending Page	105
Page Count	7
Starting Page	99
File Format	PDF
ISSN	13895729
e-ISSN	15736768
Journal	Biogerontology
Issue Number	1
Volume Number	14
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-02-01
Access Restriction	Open
Rights Holder	Springer Netherlands
Subject Keyword	Ageing Gerontology Geriatrics and Gerontology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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