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| Content Provider | PubMed Central |
|---|---|
| Author | Carrière, Audrey Liu, Xingxing Hekimi, Siegfried |
| Abstract | Two mutant mouse models of longevity in which the loss of only one copy of the gene leads to a significantly increased lifespan have recently been described: Igf1r +/- and mclk1 +/-. Igf1r encodes a transmembrane receptor kinase for the insulin-like growth factor-1, and mclk1 encodes a hydroxylase that is necessary for the biosynthesis of ubiquinone. Interestingly, the motivation for testing the longevity of both of these mutants came from observations in the nematode Caenorhabditis elegans. IGF-1R protein is homologous to DAF-2 and mCLK1 is the mouse orthologue of the C. elegans enzyme CLK-1. In worms, the homozygous inactivation of both of these longevity genes is viable and no dominant mutations are known. In addition to aging slowly, old mclk1 +/- mice were found to undergo loss-of-heterozygosity at the mclk1 locus, which results in clones of mclk1 -/- cells in the liver, presumably because mclk1 -/- cells can outcompete mclk1 +/- cells under certain conditions. We will discuss how these observations suggest novel directions of research, but also call for some caution in the interpretation of past and future results. |
| Related Links | http://dx.doi.org/10.1007/s11357-006-9006-8 |
| Ending Page | 208 |
| Page Count | 8 |
| Starting Page | 201 |
| File Format | |
| ISSN | 01619152 |
| e-ISSN | 15744647 |
| Journal | Age |
| Issue Number | 2 |
| Volume Number | 28 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2006-06-01 |
| Access Restriction | Open |
| Rights Holder | Springer Netherlands |
| Subject Keyword | Ageing Geriatrics and Gerontology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Geriatrics and Gerontology |
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