NDLI: Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Content Provider	PubMed Central
Author	Gee, Beatrice E.
Copyright Year	2013
Abstract	Current therapy for sickle cell disease (SCD) is limited to supportive treatment of complications, red blood cell transfusions, hydroxyurea, and stem cell transplantation. Difficulty in the translation of mechanistically based therapies may be the result of a reductionist approach focused on individual pathways, without having demonstrated their relative contribution to SCD complications. Many pathophysiologic processes in SCD are likely to interact simultaneously to contribute to acute vaso-occlusion or chronic vasculopathy. Applying concepts of systems biology and network medicine, models were developed to show relationships between the primary defect of sickle hemoglobin (Hb S) polymerization and the outcomes of acute pain and chronic vasculopathy. Pathophysiologic processes such as inflammation and oxidative stress are downstream by-products of Hb S polymerization, transduced through secondary pathways of hemolysis and vaso-occlusion. Pain, a common clinical trials endpoint, is also complex and may be influenced by factors outside of sickle cell polymerization and vascular occlusion. Future sickle cell research needs to better address the biologic complexity of both sickle cell disease and pain. The relevance of individual pathways to important sickle cell outcomes needs to be demonstrated in vivo before investing in expensive and labor-intensive clinical trials.
Related Links	http://dx.doi.org/10.1155/2013/694146
Starting Page	694146
File Format	PDF
ISSN	1537744X
e-ISSN	1537744X
Journal	The Scientific World Journal
Volume Number	2013
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2013-03-25
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology Environmental Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia

Morphine for the Treatment of Pain in Sickle Cell Disease

Sickle Cell Disease: New Opportunities and Challenges in Africa

Editorial: Sickle cell disease.

Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management

Morphine for the Treatment of Pain in Sickle Cell Disease

Pathology of Sickle Cell Disease

Erratum to “Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management”

Sickle cell disease in India: A perspective

Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Similar Documents

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia

Morphine for the Treatment of Pain in Sickle Cell Disease

Sickle Cell Disease: New Opportunities and Challenges in Africa

Editorial: Sickle cell disease.

Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management

Morphine for the Treatment of Pain in Sickle Cell Disease

Pathology of Sickle Cell Disease

Erratum to “Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management”

Sickle cell disease in India: A perspective

Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics