NDLI: Transgenic mouse model for central nervous system demyelination.

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Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

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Transgenic mouse model for central nervous system demyelination.

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Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene.

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Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer.

Assembly of 60S ribosomal subunits is perturbed in temperature-sensitive yeast mutants defective in ribosomal protein L16.

AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae.

Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans.

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Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.

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Transgenic mouse model for central nervous system demyelination.

Content Provider	PubMed Central
Author	Yoshioka, T. Feigenbaum, L. Jay, G.
Abstract	A common feature of demyelinating diseases such as multiple sclerosis in humans and experimental autoimmune encephalomyelitis in rodents is the marked elevation in the expression of the major histocompatibility complex (MHC) antigens in the involved sites. By specific targeting of a syngeneic MHC class I gene to oligodendrocytes, we have generated transgenic mice which not only exhibit severe involuntary tremors and develop tonic seizures but also show extensive demyelination in both the brain and the spinal cord. The fact that demyelination in these mice occurs in the absence of immune infiltration dismisses an autoimmune involvement but suggests that the MHC class I antigens play a direct role in inducing disease. Our findings lend support to the possibility that demyelinating diseases are induced by infectious agents such as viruses which can either directly activate MHC gene expression in oligodendroglia or indirectly activate expression through the release by reactive T cells of gamma interferon in the brain.
Starting Page	5479
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	11
Volume Number	11
Language	English
Publisher Date	1991-11-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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