NDLI: Functional conservation of multiple elements in yeast chromosomal replicators.

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The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.

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A targeted-replacement system for identification of signals for de novo methylation in Neurospora crassa.

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Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

Virus-encoded cyclin.

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Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.

Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

Regulation of RAG-2 protein expression in avian thymocytes.

Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

Ets-1 activates the DRA promoter in B cells.

Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

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A homeodomain protein related to caudal regulates intestine-specific gene transcription.

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Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.

cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene.

Mapping an initiation region of DNA replication at a single-copy chromosomal locus in Drosophila melanogaster cells by two-dimensional gel methods and PCR-mediated nascent-strand analysis: multiple replication origins in a broad zone.

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Comparison of DNA methylation patterns among mouse cell lines by restriction landmark genomic scanning.

Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursor.

Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing.

Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae.

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

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Active-site assembly and mode of DNA cleavage by Flp recombinase during full-site recombination.

The SR protein B52/SRp55 is essential for Drosophila development.

A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors.

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Distinct protein forms are produced from alternatively spliced bicistronic glutamic acid decarboxylase mRNAs during development.

Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.

Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer.

MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun.

Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity.

Breakpoint junctions of chromosome 9p deletions in two human glioma cell lines.

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

Isolation of a thyroid hormone-responsive gene by immunoprecipitation of thyroid hormone receptor-DNA complexes.

Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.

Functional conservation of multiple elements in yeast chromosomal replicators.

Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function.

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

Identification of cut8 + and cek1 +, a Novel Protein Kinase Gene, Which Complement a Fission Yeast Mutation That Blocks Anaphase

Two Saccharomyces cerevisiae Genes Which Control Sensitivity To G1 Arrest Induced by Kluyveromyces lactis Toxin

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Functional conservation of multiple elements in yeast chromosomal replicators.

Content Provider	PubMed Central
Author	Rao, H. Marahrens, Y. Stillman, B.
Abstract	Replicators that control the initiation of DNA replication in the chromosomes of Saccharomyces cerevisiae retain their function when cloned into plasmids, where they are commonly referred to as autonomously replicating sequences (ARSs). Previous studies of the structure of ARS1 in both plasmid and chromosome contexts have shown that it contains one essential DNA element, A, that includes a match to the ARS consensus sequence (ACS), and three additional elements, B1, B2, and B3, that are also important for ARS function. Elements A and B3 are bound by a candidate initiator protein called the origin recognition complex and ARS-binding factor 1, respectively. Although the A and B3 elements have been found in other ARSs, sequence comparisons among ARSs have failed to identify B1- and B2-like elements. To assess the generality of the modular nature of yeast replicators, linker substitution mutagenesis of another yeast chromosomal replicator, ARS307, was performed. Three DNA sequence elements were identified in ARS307, and they were demonstrated to be functionally equivalent to the A, B1, and B2 elements present in ARS1. Despite the lack of DNA sequence similarity, the B1 and B2 elements at each ARS were functionally conserved. Single-base substitutions in the core of the ARS1 B1 and B2 elements identified critical nucleotides required for the function of the B1 element. In contrast, no single-point mutations were found to affect B2 function. The results suggest that multiple DNA sequence elements might be a general and conserved feature of replicator sequences in S. cerevisiae.
Starting Page	7643
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	11
Volume Number	14
Language	English
Publisher Date	1994-11-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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