NDLI: The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.

Please wait, while we are loading the content...

Year: 2016, Volume: 36

Year: 2015, Volume: 36

Year: 2015, Volume: 35

Year: 2014, Volume: 35

Year: 2014, Volume: 34

Year: 2013, Volume: 33

Year: 2012, Volume: 32

Year: 2011, Volume: 31

Year: 2010, Volume: 30

Year: 2009, Volume: 29

Year: 2008, Volume: 28

Year: 2007, Volume: 27

Year: 2006, Volume: 26

Year: 2005, Volume: 25

Year: 2004, Volume: 24

Year: 2003, Volume: 23

Year: 2002, Volume: 23

Year: 2002, Volume: 22

Year: 2001, Volume: 21

Year: 2000, Volume: 20

Year: 1999, Volume: 19

Year: 1998, Volume: 18

Year: 1997, Volume: 17

Year: 1996, Volume: 16

Year: 1995, Volume: 15

Year: 1994, Volume: 14

Year: 1994, Volume: 14, Issue: 12

Year: 1994, Volume: 14, Issue: 11

The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.

Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor gene.

A targeted-replacement system for identification of signals for de novo methylation in Neurospora crassa.

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes.

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.

A novel synapse-associated noncoding RNA.

Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors.

A novel, cell-type-specific mechanism for estrogen receptor-mediated gene activation in the absence of an estrogen-responsive element.

Reciprocal regulation of the Epstein-Barr virus BamHI-F promoter by EBNA-1 and an E2F transcription factor.

Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf.

The REC2 gene encodes the homologous pairing protein of Ustilago maydis.

p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.

Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts.

Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.

A monomeric derivative of the cellular transcription factor CREB functions as a constitutive activator.

Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators.

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

Virus-encoded cyclin.

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.

Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

Regulation of RAG-2 protein expression in avian thymocytes.

Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

Ets-1 activates the DRA promoter in B cells.

Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.

A homeodomain protein related to caudal regulates intestine-specific gene transcription.

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins.

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.

cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene.

Mapping an initiation region of DNA replication at a single-copy chromosomal locus in Drosophila melanogaster cells by two-dimensional gel methods and PCR-mediated nascent-strand analysis: multiple replication origins in a broad zone.

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction.

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

Comparison of DNA methylation patterns among mouse cell lines by restriction landmark genomic scanning.

Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursor.

Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing.

Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae.

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

ralGDS family members interact with the effector loop of ras p21.

Active-site assembly and mode of DNA cleavage by Flp recombinase during full-site recombination.

The SR protein B52/SRp55 is essential for Drosophila development.

A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors.

The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.

Distinct protein forms are produced from alternatively spliced bicistronic glutamic acid decarboxylase mRNAs during development.

Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.

Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer.

MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun.

Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity.

Breakpoint junctions of chromosome 9p deletions in two human glioma cell lines.

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

Isolation of a thyroid hormone-responsive gene by immunoprecipitation of thyroid hormone receptor-DNA complexes.

Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.

Functional conservation of multiple elements in yeast chromosomal replicators.

Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function.

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

Identification of cut8 + and cek1 +, a Novel Protein Kinase Gene, Which Complement a Fission Yeast Mutation That Blocks Anaphase

Two Saccharomyces cerevisiae Genes Which Control Sensitivity To G1 Arrest Induced by Kluyveromyces lactis Toxin

Year: 1994, Volume: 14, Issue: 10

Year: 1994, Volume: 14, Issue: 9

Year: 1994, Volume: 14, Issue: 8

Year: 1994, Volume: 14, Issue: 7

Year: 1994, Volume: 14, Issue: 6

Year: 1994, Volume: 14, Issue: 5

Year: 1994, Volume: 14, Issue: 4

Year: 1994, Volume: 14, Issue: 3

Year: 1994, Volume: 14, Issue: 2

Year: 1994, Volume: 14, Issue: 1

Year: 1993, Volume: 13

Year: 1992, Volume: 12

Year: 1991, Volume: 11

Year: 1990, Volume: 10

Year: 1989, Volume: 9

Year: 1988, Volume: 8

Year: 1987, Volume: 7

Year: 1986, Volume: 6

Year: 1985, Volume: 5

Year: 1984, Volume: 4

Year: 1983, Volume: 3

Year: 1982, Volume: 2

Year: 1981, Volume: 1

The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements.

Content Provider	PubMed Central
Author	Navankasattusas, S. Sawadogo, M. Van Bilsen, M. Chien, K. R. Dang, C. V.
Abstract	Previous studies have documented that 250 bp of the rat cardiac ventricular myosin light-chain 2 (MLC-2v) promoter is sufficient to confer cardiac muscle-specific expression on a luciferase reporter gene in both transgenic mice and primary cultured neonatal rat myocardial cells. Utilizing ligation-mediated PCR to perform in vivo dimethyl sulfate footprinting, the present study has identified protein-DNA interaction within the position from -176 to -165. This region, identified as MLE1, contains a core sequence, CACGTG, which conforms to the consensus E-box site and is identical to the upstream stimulating factor (USF)-binding site of the adenovirus major late promoter. Transient assays of luciferase reporter genes containing point mutations of the site demonstrate the importance of this cis regulatory element in the transcriptional activation of this cardiac muscle gene in ventricular muscle cells. The protein complex that occupies this site is capable of binding to HF-1a and PRE B sites which are known to be required for cardiac muscle-specific expression of rat MLC-2v and alpha-myosin heavy-chain genes, respectively. This study provides direct evidence that USF, a member of the basic helix-loop-helix leucine zipper family, binds to MLE1, HF-1a, and PRE B sites and suggests that it is a component of protein complexes that may coordinately control the expression of MLC-2v and alpha-myosin heavy-chain genes. The current study also provides evidence that USF can positively and negatively regulate the MLC-2v gene via independent cis regulatory elements.
Starting Page	7331
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	11
Volume Number	14
Language	English
Publisher Date	1994-11-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in