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  1. Annual review of immunology
  2. Year: 2012, Volume: 30
  3. Year: 2012, Volume: 30, Issue: Unspecified
  4. Adaptive Immunity to Fungi
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Year: 2015, Volume: 33
Year: 2014, Volume: 32
Year: 2013, Volume: 31
Year: 2012, Volume: 30
Year: 2012, Volume: 30, Issue: Unspecified
Reflex Principles of Immunological Homeostasis
Signaling by myeloid C-type lectin receptors in immunity and homeostasis
Transcriptional and Epigenetic Control of T Cell Lineage Specification: Molecular Mechanisms Underlying Commitment and Plasticity
VLR-Based Adaptive Immunity
Regulation of Immune Responses by mTOR
Selection of self-reactive T cells in the thymus
The Response to and Repair of RAG-Mediated DNA Double Stranded Breaks
Adaptive Immunity to Fungi
Siglecs and Immune Regulation
The Microbiome in Infectious Disease and Inflammation
Year: 2011, Volume: 29
Year: 2010, Volume: 28
Year: 2009, Volume: 27
Year: 2008, Volume: 26
Year: 2007, Volume: 25
Year: 2005, Volume: 23

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Adaptive Immunity to Fungi

Content Provider PubMed Central
Author Wüthrich, Marcel Deepe, George S. Klein, Bruce
Copyright Year 2012
Abstract Only a handful of the more than 100,000 fungal species on our planet cause disease in humans, yet the number of life-threatening fungal infections in patients has recently skyrocketed as a result of advances in medical care that often suppress immunity intensely. This emerging crisis has created pressing needs to clarify immune defense mechanisms against fungi, with the ultimate goal of therapeutic applications. Herein, we describe recent insights in understanding the mammalian immune defenses deployed against pathogenic fungi. The review focuses on adaptive immune responses to the major medically important fungi and emphasizes how dendritic cells and subsets in various anatomic compartments respond to fungi, recognize their molecular patterns, and signal responses that nurture and shape the differentiation of T cell subsets and B cells. Also emphasized is how the latter deploy effector and regulatory mechanisms that eliminate these nasty invaders while also constraining collateral damage to vital tissue.
Related Links http://dx.doi.org/10.1146/annurev-immunol-020711-074958
Ending Page 148
Page Count 34
Starting Page 115
File Format PDF
ISSN 07320582
e-ISSN 15453278
Journal Annual review of immunology
Volume Number 30
Language English
Publisher Date 2012-04-23
Access Restriction Open
Subject Keyword Immunology Immunology and Allergy Research in Higher Education
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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