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  1. Annual review of immunology
  2. Year: 2012, Volume: 30
  3. Year: 2012, Volume: 30, Issue: Unspecified
  4. VLR-Based Adaptive Immunity
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Year: 2015, Volume: 33
Year: 2014, Volume: 32
Year: 2013, Volume: 31
Year: 2012, Volume: 30
Year: 2012, Volume: 30, Issue: Unspecified
Reflex Principles of Immunological Homeostasis
Signaling by myeloid C-type lectin receptors in immunity and homeostasis
Transcriptional and Epigenetic Control of T Cell Lineage Specification: Molecular Mechanisms Underlying Commitment and Plasticity
VLR-Based Adaptive Immunity
Regulation of Immune Responses by mTOR
Selection of self-reactive T cells in the thymus
The Response to and Repair of RAG-Mediated DNA Double Stranded Breaks
Adaptive Immunity to Fungi
Siglecs and Immune Regulation
The Microbiome in Infectious Disease and Inflammation
Year: 2011, Volume: 29
Year: 2010, Volume: 28
Year: 2009, Volume: 27
Year: 2008, Volume: 26
Year: 2007, Volume: 25
Year: 2005, Volume: 23

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VLR-Based Adaptive Immunity

Content Provider PubMed Central
Author Boehm, Thomas Mccurley, Nathanael Yoichi, Sutoh Michael, Schorpp Kasahara, Masanori Cooper, Max D.
Copyright Year 2012
Abstract Lampreys and hagfish are primitive jawless vertebrates capable of mounting specific immune responses. Lampreys possess different types of lymphocytes, akin to T and B cells of jawed vertebrates, that clonally express somatically diversified antigen receptors termed variable lymphocyte receptors (VLRs), which are composed of tandem arrays of leucine-rich repeats. The VLRs appear to be diversified by a gene conversion mechanism involving lineage-specific cytosine deaminases. VLRA is expressed on the surface of T-like lymphocytes; B-like lymphocytes express and secrete VLRB as a multivalent protein. VLRC is expressed by a distinct lymphocyte lineage. VLRA-expressing cells appear to develop in a thymus-like tissue at the tip of gill filaments, and VLRB-expressing cells develop in hematopoietic tissues. Reciprocal expression patterns of evolutionarily conserved interleukins and chemokines possibly underlie cell-cell interactions during an immune response. The discovery of VLRs in agnathans illuminates the origins of adaptive immunity in early vertebrates.
Related Links http://dx.doi.org/10.1146/annurev-immunol-020711-075038
Ending Page 220
Page Count 18
Starting Page 203
File Format PDF
ISSN 07320582
e-ISSN 15453278
Journal Annual review of immunology
Volume Number 30
Language English
Publisher Date 2012-04-23
Access Restriction Open
Subject Keyword Immunology Immunology and Allergy Research in Higher Education
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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