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| Content Provider | PubMed Central |
|---|---|
| Author | Boehm, Thomas Mccurley, Nathanael Yoichi, Sutoh Michael, Schorpp Kasahara, Masanori Cooper, Max D. |
| Copyright Year | 2012 |
| Abstract | Lampreys and hagfish are primitive jawless vertebrates capable of mounting specific immune responses. Lampreys possess different types of lymphocytes, akin to T and B cells of jawed vertebrates, that clonally express somatically diversified antigen receptors termed variable lymphocyte receptors (VLRs), which are composed of tandem arrays of leucine-rich repeats. The VLRs appear to be diversified by a gene conversion mechanism involving lineage-specific cytosine deaminases. VLRA is expressed on the surface of T-like lymphocytes; B-like lymphocytes express and secrete VLRB as a multivalent protein. VLRC is expressed by a distinct lymphocyte lineage. VLRA-expressing cells appear to develop in a thymus-like tissue at the tip of gill filaments, and VLRB-expressing cells develop in hematopoietic tissues. Reciprocal expression patterns of evolutionarily conserved interleukins and chemokines possibly underlie cell-cell interactions during an immune response. The discovery of VLRs in agnathans illuminates the origins of adaptive immunity in early vertebrates. |
| Related Links | http://dx.doi.org/10.1146/annurev-immunol-020711-075038 |
| Ending Page | 220 |
| Page Count | 18 |
| Starting Page | 203 |
| File Format | |
| ISSN | 07320582 |
| e-ISSN | 15453278 |
| Journal | Annual review of immunology |
| Volume Number | 30 |
| Language | English |
| Publisher Date | 2012-04-23 |
| Access Restriction | Open |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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