NDLI: Altered Network Communication Following a Neuroprotective Drug Treatment

Content Provider	PubMed Central
Author	Vincent, Kathleen Tauskela, Joseph S. Mealing, Geoffrey A. Thivierge, Jean-philippe
Editor	Rota, Rossella
Copyright Year	2013
Abstract	Preconditioning is defined as a range of stimuli that allow cells to withstand subsequent anaerobic and other deleterious conditions. While cell protection under preconditioning is well established, this paper investigates the influence of neuroprotective preconditioning drugs, 4-aminopyridine and bicuculline (4-AP/bic), on synaptic communication across a broad network of in vitro rat cortical neurons. Using a permutation test, we evaluated cross-correlations of extracellular spiking activity across all pairs of recording electrodes on a 64-channel multielectrode array. The resulting functional connectivity maps were analyzed in terms of their graph-theoretic properties. A small-world effect was found, characterized by a functional network with high clustering coefficient and short average path length. Twenty-four hours after exposure to 4-AP/bic, small-world properties were comparable to control cultures that were not treated with the drug. Four hours following drug washout, however, the density of functional connections increased, while path length decreased and clustering coefficient increased. These alterations in functional connectivity were maintained at four days post-washout, suggesting that 4-AP/bic preconditioning leads to long-term effects on functional networks of cortical neurons. Because of their influence on communication efficiency in neuronal networks, alterations in small-world properties hold implications for information processing in brain systems. The observed relationship between density, path length, and clustering coefficient is captured by a phenomenological model where connections are added randomly within a spatially-embedded network. Taken together, results provide information regarding functional consequences of drug therapies that are overlooked in traditional viability studies and present the first investigation of functional networks under neuroprotective preconditioning.
Related Links	http://dx.doi.org/10.1371/journal.pone.0054478
Starting Page	54478
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	1
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Altered Hub Configurations within Default Mode Network following Acupuncture at ST36: A Multimodal Investigation Combining fMRI and MEG

Enhanced Transmission of Drug-Resistant Parasites to Mosquitoes following Drug Treatment in Rodent Malaria

Resting Network Plasticity Following Brain Injury

Altered Synaptic Properties During Integration of Adult-Born Hippocampal Neurons Following a Seizure Insult

Altered Error Processing following Vascular Thalamic Damage: Evidence from an Antisaccade Task

Altered Anatomical Network in Early Blindness Revealed by Diffusion Tensor Tractography

The Geospatial Characteristics of a Social Movement Communication Network

Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State: A Small-World Brain Network Study

A Social Network Analysis of Treatment Discoveries in Cancer

Altered Network Communication Following a Neuroprotective Drug Treatment

Similar Documents

Altered Hub Configurations within Default Mode Network following Acupuncture at ST36: A Multimodal Investigation Combining fMRI and MEG

Enhanced Transmission of Drug-Resistant Parasites to Mosquitoes following Drug Treatment in Rodent Malaria

Resting Network Plasticity Following Brain Injury

Altered Synaptic Properties During Integration of Adult-Born Hippocampal Neurons Following a Seizure Insult

Altered Error Processing following Vascular Thalamic Damage: Evidence from an Antisaccade Task

Altered Anatomical Network in Early Blindness Revealed by Diffusion Tensor Tractography

The Geospatial Characteristics of a Social Movement Communication Network

Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State: A Small-World Brain Network Study

A Social Network Analysis of Treatment Discoveries in Cancer

Altered Network Communication Following a Neuroprotective Drug Treatment