NDLI: Phospholipase Cγ2 plays a role in T-cell receptor signal transduction and T-cell selection 1

Content Provider	PubMed Central
Author	Fu, Guoping Chen, Yuhong Schuman, James Wang, Demin Wen, Renren
Abstract	One of the important signaling events following T-cell receptor (TCR) engagement is activation of phospholipase Cγ (PLCγ). PLCγ has two isoforms, PLCγ1 and PLCγ2. It is known that PLCγ1 is important for TCR signaling and TCR-mediated T-cell selection and functions whereas PLCγ2 is critical for B-cell receptor (BCR) signal transduction and BCR-mediated B-cell maturation and functions. Here we report that PLCγ2 was expressed in primary T cells, and became associated with LAT and SLP-76 and activated upon TCR stimulation. PLCγ1/PLCγ2 double-deficient T cells displayed further block from CD4 and CD8 double positive to single positive transition compared to PLCγ1 single-deficient T cells. TCR-mediated proliferation was further impaired in PLCγ1/PLCγ2 double-deficient T cells compared PLCγ1 single-deficient T cells. TCR-mediated signal transduction, including Ca2+ mobilization and Erk activation, was further impaired in PLCγ1/PLCγ2 double-deficient relative to PLCγ1 single-deficient T cells. In addition, in HY TCR transgenic mouse model, thymic positive and negative selections were reduced in PLCγ1 heterozygous- and PLCγ2 homozygous-deficient (PLCγ1+/−PLCγ2−/−) relative to wild-type, PLCγ2 single-deficient (PLCγ2−/−), or PLCγ1 heterozygous-deficient (PLCγ1+/−) mice. Taken together, these data demonstrate that PLCγ2 participates in TCR signal transduction and plays a role in T-cell selection.
Related Links	http://dx.doi.org/10.4049/jimmunol.1103458
Ending Page	2332
Page Count	7
Starting Page	2326
File Format	PDF
ISSN	15506606
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	5
Volume Number	189
Language	English
Publisher Date	2012-09-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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