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Self-assembled Aptamer-based Drug Carriers for Bi-specific Cytotoxicity to Cancer Cells
| Content Provider | PubMed Central |
|---|---|
| Author | Zhu, Guizhi Meng, Ling Ye, Mao Yang, Liu Kwame, Sefah O’donoghue, Meghan B. Chen, Yan Xiong, Xiangling Huang, Jin Song, Erqun Tan, Weihong |
| Abstract | Monovalent aptamers can deliver drugs to target cells by specific recognition. However, different cancer subtypes are distinguished by heterogeneous biomarkers, and one single aptamer was unable to recognize all clinical samples from different patients with even the same type of cancers. To address heterogeneity among cancer subtypes for targeted drug delivery, as a model, we developed a drug carrier with broader recognition range of cancer subtypes. This carrier (SD) was self-assembled from two modified monovalent aptamers. It showed bi-specific recognition abilities to target cells in cell mixtures, thus broadening the recognition capabilities of its parent aptamers. The self-assembly of SD simultaneously formed multiple drug loading sites for anticancer drug Doxorubicin (Dox). The Dox-loaded SD (SD-Dox) also showed bi-specific abilities of target cell binding and drug delivery. Most importantly, SD-Dox induced bi-specific cytotoxicity in target cells in cell mixtures. Therefore, by broadening the otherwise limited recognition capabilities of monovalent aptamers, bi-specific aptamer-based drug carriers would facilitate aptamer applications for clinically heterogeneous cancer subtypes which respond to the same cancer therapy. |
| Related Links | http://dx.doi.org/10.1002/asia.201101060 |
| Starting Page | 1630 |
| File Format | |
| ISSN | 1861471X |
| e-ISSN | 1861471X |
| Journal | Chemistry, an Asian journal |
| Issue Number | 7 |
| Volume Number | 7 |
| Language | English |
| Publisher Date | 2012-06-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry |
