NDLI: Adipocyte iron regulates adiponectin and insulin sensitivity

Content Provider	PubMed Central
Author	Gabrielsen, J. Scott Gao, Yan Simcox, Judith A. Huang, Jingyu Thorup, David Jones, Deborah Cooksey, Robert C. Gabrielsen, David Adams, Ted D. Hunt, Steven C. Hopkins, Paul N. Cefalu, William T. Mcclain, Donald A.
Copyright Year	2012
Abstract	Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inflammation. Ferritin was increased and adiponectin was decreased in type 2 diabetic and in obese diabetic subjects compared with those in equally obese individuals without metabolic syndrome. Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression. Further, loss of the adipocyte iron export channel, ferroportin, in mice resulted in adipocyte iron loading, decreased adiponectin, and insulin resistance. Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity. Phlebotomy of humans with impaired glucose tolerance and ferritin values in the highest quartile of normal increased adiponectin and improved glucose tolerance. These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores.
Related Links	http://dx.doi.org/10.1172/jci44421
Ending Page	3540
Page Count	12
Starting Page	3529
File Format	PDF
ISSN	00219738
e-ISSN	15588238
Journal	The Journal of Clinical Investigation
Issue Number	10
Volume Number	122
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2012-10-01
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Adipocyte iron regulates leptin and food intake

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Iron Metabolism Is Associated With Adipocyte Insulin Resistance and Plasma Adiponectin

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice

Modulation of iron metabolism by iron chelation regulates intracellular calcium and increases sensitivity to doxorubicin

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

Liraglutide Increases FGF-21 Activity and Insulin Sensitivity in High Fat Diet and Adiponectin Knockdown Induced Insulin Resistance

Adipocyte iron regulates adiponectin and insulin sensitivity

Similar Documents

Adipocyte iron regulates leptin and food intake

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Iron Metabolism Is Associated With Adipocyte Insulin Resistance and Plasma Adiponectin

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice

Modulation of iron metabolism by iron chelation regulates intracellular calcium and increases sensitivity to doxorubicin

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

Liraglutide Increases FGF-21 Activity and Insulin Sensitivity in High Fat Diet and Adiponectin Knockdown Induced Insulin Resistance

Adipocyte iron regulates adiponectin and insulin sensitivity