NDLI: Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

Content Provider	PubMed Central
Author	Eduardo, Peixoto-santos José Galvis-alonso, Orfa Yineth Velasco, Tonicarlo Rodrigues Kandratavicius, Ludmyla Assirati, João Alberto Carlotti, Carlos Gilberto Scandiuzzi, Renata Caldo Serafini, Luciano Neder Leite, João Pereira
Editor	Sensi, Stefano L.
Copyright Year	2012
Abstract	In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) and patients with TLE associated with tumor or dysplasia (TLE-TD) were evaluated for expression of MT-I/II, for the vesicular zinc levels, and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis, microgliosis and reduced neuronal population. In TLE-TD, the same changes were observed, except that were mainly confined to fascia dentata. Increased vesicular zinc was observed only in the inner molecular layer of MTLE patients, when compared to control cases. Correlation and linear regression analyses indicated an association between increased MT-I/II and increased astrogliosis in TLE. MT-I/II levels did not correlate with any clinical variables, but MTLE patients with secondary generalized seizures (SGS) had less MT-I/II than MTLE patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from TLE patients and our data suggest that it is associated with astrogliosis and may be associated with different seizure spread patterns.
Related Links	http://dx.doi.org/10.1371/journal.pone.0044709
Starting Page	44709
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Changes in Functional Integration with the Non-Epileptic Temporal Lobe of Patients with Unilateral Mesiotemporal Epilepsy

Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy

Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Correction: Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings

Stability of Synchronization Clusters and Seizurability in Temporal Lobe Epilepsy

Heritability of Subcortical Volumetric Traits in Mesial Temporal Lobe Epilepsy

Perfusion Network Shift during Seizures in Medial Temporal Lobe Epilepsy

Subjective Memory Evaluation before and after Temporal Lobe Epilepsy Surgery

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

Similar Documents

Changes in Functional Integration with the Non-Epileptic Temporal Lobe of Patients with Unilateral Mesiotemporal Epilepsy

Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy

Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Correction: Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings

Stability of Synchronization Clusters and Seizurability in Temporal Lobe Epilepsy

Heritability of Subcortical Volumetric Traits in Mesial Temporal Lobe Epilepsy

Perfusion Network Shift during Seizures in Medial Temporal Lobe Epilepsy

Subjective Memory Evaluation before and after Temporal Lobe Epilepsy Surgery

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy