NDLI: Assessing Graphene Nanopores for Sequencing DNA

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Assessing Graphene Nanopores for Sequencing DNA

Content Provider	PubMed Central
Author	Wells, David B. Belkin, Maxim Comer, Jeffrey Aksimentiev, Aleksei
Abstract	Using all-atom molecular dynamics and atomic-resolution Brownian dynamics, we simulate the translocation of single-stranded DNA through graphene nanopores and characterize the ionic current blockades produced by DNA nucleotides. We find that transport of single DNA strands through graphene nanopores may occur in single nucleotide steps. For certain pore geometries, hydrophobic interactions with the graphene membrane lead to a dramatic reduction in the conformational fluctuations of the nucleotides in the nanopores. Furthermore, we show that ionic current blockades produced by different DNA nucleotides are, in general, indicative of the nucleotide type, but very sensitive to the orientation of the nucleotides in the nanopore. Taken together, our simulations suggest that strand sequencing of DNA by measuring the ionic current blockades in graphene nanopores may be possible, given that the conformation of DNA nucleotides in the nanopore can be controlled through precise engineering of the nanopore surface.
Related Links	http://dx.doi.org/10.1021/nl301655d
Ending Page	4123
Page Count	7
Starting Page	4117
File Format	PDF
ISSN	15306984
e-ISSN	15306992
Journal	Nano letters
Issue Number	8
Volume Number	12
Language	English
Publisher Date	2012-08-08
Access Restriction	Open
Subject Keyword	Mechanical Engineering Materials Science(all) Bioengineering Chemistry(all) Condensed Matter Physics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Condensed Matter Physics Mechanical Engineering Bioengineering

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