NDLI: Fast DNA sequencing via transverse electronic transport

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Fast DNA sequencing via transverse electronic transport

Content Provider	PubMed Central
Author	Lagerqvist, Johan Zwolak, Michael Di Ventra, Massimiliano
Abstract	A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, e.g., orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict and cure diseases from the perspective of the genetic makeup of each individual.
Related Links	http://dx.doi.org/10.1021/nl0601076
Ending Page	782
Page Count	4
Starting Page	779
File Format	PDF
ISSN	15306984
e-ISSN	15306992
Journal	Nano letters
Issue Number	4
Volume Number	6
Language	English
Publisher Date	2006-04-01
Access Restriction	Open
Subject Keyword	Mechanical Engineering Materials Science(all) Bioengineering Chemistry(all) Condensed Matter Physics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Condensed Matter Physics Mechanical Engineering Bioengineering

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