NDLI: cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration

Content Provider	PubMed Central
Author	Rebecca, Berdeaux Stewart, Randi
Copyright Year	2012
Abstract	Among organ systems, skeletal muscle is perhaps the most structurally specialized. The remarkable subcellular architecture of this tissue allows it to empower movement with instructions from motor neurons. Despite this high degree of specialization, skeletal muscle also has intrinsic signaling mechanisms that allow adaptation to long-term changes in demand and regeneration after acute damage. The second messenger adenosine 3′,5′-monophosphate (cAMP) not only elicits acute changes within myofibers during exercise but also contributes to myofiber size and metabolic phenotype in the long term. Strikingly, sustained activation of cAMP signaling leads to pronounced hypertrophic responses in skeletal myofibers through largely elusive molecular mechanisms. These pathways can promote hypertrophy and combat atrophy in animal models of disorders including muscular dystrophy, age-related atrophy, denervation injury, disuse atrophy, cancer cachexia, and sepsis. cAMP also participates in muscle development and regeneration mediated by muscle precursor cells; thus, downstream signaling pathways may potentially be harnessed to promote muscle regeneration in patients with acute damage or muscular dystrophy. In this review, we summarize studies implicating cAMP signaling in skeletal muscle adaptation. We also highlight ligands that induce cAMP signaling and downstream effectors that are promising pharmacological targets.
Related Links	http://dx.doi.org/10.1152/ajpendo.00555.2011
Starting Page	1
File Format	PDF
ISSN	01931849
e-ISSN	15221555
Journal	American Journal of Physiology - Endocrinology and Metabolism
Issue Number	1
Volume Number	303
Language	English
Publisher	American Physiological Society
Publisher Date	2012-07-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Endocrinology, Diabetes and Metabolism Physiology (medical)

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