NDLI: MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance

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MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance

Content Provider	PubMed Central
Author	Kwon, Oh Sung Tanner, Ruth E. Barrows, Katherine M. Marah, Runtsch Symons, J. David Jalili, Thunder Bikman, Benjamin T. Mcclain, Donald A. O'connell, Ryan M. Drummond, Micah J.
Copyright Year	2015
Abstract	Physical inactivity in older adults is a risk factor for developing glucose intolerance and impaired skeletal muscle function. Elevated inflammation and ceramide biosynthesis have been implicated in metabolic disruption and are linked to Toll-like receptor (TLR)/myeloid differentiation primary response 88 (MyD88) signaling. We hypothesize that a physical inactivity stimulus, capable of inducing glucose intolerance, would increase skeletal muscle inflammation and ceramide biosynthesis signaling and that this response would be regulated by the TLR/MyD88 pathway. Therefore, we subjected wild-type (WT) and MyD88−/− mice to hindlimb unloading (HU) for 14 days or an ambulatory control period. We observed impaired glucose uptake, muscle insulin signaling (p-Akt), and increased markers of NF-κB signaling (p-IκBα), inflammation (p-JNK, IL-6), TLR4, and the rate-limiting enzyme of ceramide biosynthesis, SPT2, with HU WT (P < 0.05), but not in HU MyD88−/− mice. Concurrently, we found that 5 days of bed rest in older adults resulted in whole body glucose dysregulation, impaired skeletal muscle insulin signaling, and upregulation of muscle IL-6 and SPT2 (P < 0.05). Post-bed rest TLR4 abundance was tightly correlated with impaired postprandial insulin and glucose levels. In conclusion, MyD88 signaling is necessary for the increased inflammation, ceramide biosynthesis signaling, and compromised metabolic function that accompanies physical inactivity.
Related Links	http://dx.doi.org/10.1152/ajpendo.00124.2015
Starting Page	11
File Format	PDF
ISSN	01931849
e-ISSN	15221555
Journal	American Journal of Physiology - Endocrinology and Metabolism
Issue Number	1
Volume Number	309
Language	English
Publisher	American Physiological Society
Publisher Date	2015-07-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Endocrinology, Diabetes and Metabolism Physiology (medical)

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MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance