NDLI: Virus-specific CD8+ T cells up-regulate PD-1 expression during acute Friend retrovirus infection but are highly cytotoxic and control virus replication

Content Provider	PubMed Central
Author	Zelinskyy, Gennadiy Myers, Lara Dietze, Kirsten K. Gibbert, Kathrin Roggendorf, Michael Liu, Jia Lu, Mengji Kraft, Anke R. Volker, Teichgräber Hasenkrug, Kim J. Dittmer, Ulf
Abstract	It was recently reported that inhibitory molecules such as PD-1 were up-regulated on CD8+ T cells during acute Friend retrovirus infection, and that the cells were prematurely exhausted and dysfunctional in vitro. The current study confirms that most activated CD8+ T cells up-regulated expression of PD-1 during acute infection and revealed a dichotomy of function between PD-1hi and PD-1lo subsets. More PD-1lo cells produced anti-viral cytokines such as IFNγ and TNFα, while more PD-1hi cells displayed characteristics of cytotoxic effectors such as production of granzymes and surface expression of CD107a. Importantly, CD8+ T cells mediated rapid in vivo cytotoxicity and were critical for control of acute Friend virus replication. Thus direct ex vivo analyses and in vivo experiments revealed high CD8+ T cell functionality and indicate that PD-1 expression during acute infection is not a marker of T cell exhaustion.
Related Links	http://dx.doi.org/10.4049/jimmunol.1101612
Ending Page	3737
Page Count	8
Starting Page	3730
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of Immunology (Baltimore, Md. : 1950)
Issue Number	7
Volume Number	187
Language	English
Publisher Date	2011-10-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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